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STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY OFFICE OF ENVIRONMENTAL HEALTH HAZARD ASSESSMENT SAFE DRINKING WATER AND TOXIC ENFORCEMENT ACT OF 1986 CHEMICALS KNOWN TO THE STATE TO CAUSE CANCER OR REPRODUCTIVE TOXICITY 17-Feb-12 The Safe Drinking Water and Toxic Enforcement Act of 1986 requires that the Governor revise and republish at least once per year the list of chemicals known to the State to cause cancer or reproductive toxicity. For easy reference, chemicals which are newly added are shown in underline. Chemicals or endpoints shown in strikeout were placed on the Proposition 65 list on the date noted, and have subsequently been removed. A hyperlink is provided for the basis for removing the chemical. In the Listing Mechanism column, "AB" denotes authoritative bodies, "SQE" denotes State's Qualified Experts, "FR" denotes formally required to be labeled or identified, and "LC" denotes Labor Code. For those chemicals for which the basis for listing documentation is available electronically, a hyperlink to the documentation is provided. The identification number indicated in the following list is the Chemical Abstracts Service (CAS) Registry Number. No CAS number is given when several substances are presented as a single listing. The date refers to the initial appearance of the chemical on the list. For those chemicals for which a no significant risk level (NSRL) for carcinogens or maximum allowable dose level (MADL) for reproductive toxicants has been adopted, it is denoted in the column, "NSRL or MADL." For those NSRLs or MADLs for which the risk assessment documentation is available electronically, a hyperlink to the documentation is provided.
Chemical
A-alpha-C (2-Amino-9H-pyrido[2,3b]indole) Acetaldehyde Acetamide Acetazolamide Acetochlor Acetohydroxamic acid 2-Acetylaminofluorene Acifluorfen sodium Acrylamide Acrylamide Acrylonitrile Actinomycin D Actinomycin D
Type of Toxicity
cancer cancer cancer developmental cancer developmental cancer cancer cancer developmental, male cancer cancer developmental -1-
Listing Mechanism
AB SQE AB FR
SQE FR SQE AB AB AB
FR LC FR
CAS No.
Date Listed
26148-68-5 75-07-0 60-35-5 59-66-5 34256-82-1 546-88-3 53-96-3 62476-59-9 79-06-1
1-Jan-90 1-Apr-88 1-Jan-90 20-Aug-99 1-Jan-89 1-Apr-90 1-Jul-87 1-Jan-90 1-Jan-90
79-06-1 107-13-1 50-76-0 50-76-0
25-Feb-11 1-Jul-87 1-Oct-89 1-Oct-92
Listing Mechanism
CAS No.
cancer cancer cancer
SQE SQE SQE
3688-53-7 --15972-60-8
1-Jul-87 1-Jan-88 1-Jan-89
cancer cancer developmental
SQE SQE SQE
--309-00-2 302-79-4
1-Jul-88 1-Jul-88 1-Jan-89
AB FR
107-05-1 28981-97-7
1-Jan-90 1-Jul-90
Altretamine Amantadine hydrochloride Amikacin sulfate 2-Aminoanthraquinone p -Aminoazobenzene o -Aminoazotoluene
cancer developmental developmental, male developmental developmental cancer cancer cancer
FR FR
FR LC AB SQE
645-05-6 665-66-7 39831-55-5 117-79-3 60-09-3 97-56-3
20-Aug-99 27-Feb-01 1-Jul-90 1-Oct-89 1-Jan-90 1-Jul-87
4-Aminobiphenyl (4-aminodiphenyl)
cancer
LC
92-67-1
27-Feb-87
1-Amino-2,4-dibromoanthraquinone 3-Amino-9-ethylcarbazole hydrochloride 2-Aminofluorene Aminoglutethimide Aminoglycosides 1-Amino-2-methylanthraquinone 2-Amino-5-(5-nitro-2-furyl)-1,3,4thiadiazole 4-Amino-2-nitrophenol
cancer
AB
81-49-2
26-Aug-97
cancer cancer developmental developmental cancer
SQE
6109-97-3 153-78-6 125-84-8 --82-28-0
1-Jul-89 29-Jan-99 1-Jul-90 1-Oct-92 1-Oct-89
cancer cancer developmental, female developmental, female, male developmental cancer developmental cancer developmental female, male
SQE SQE
712-68-5 119-34-6
1-Jul-87 29-Jan-99
SQE
54-62-6
1-Jul-87
FR AB
19774-82-4 33089-61-1 61-82-5 14028-44-5 51264-14-3 994-05-8 ---
26-Aug-97 30-Mar-99 1-Jul-87 15-May-98 7-Aug-09 18-Dec-09 1-Apr-90
AB
--63-05-8
27-Feb-87 3-May-11
FR
---
Chemical AF-2;[2-(2-furyl)-3-(5-nitro-2furyl)]acrylamide Aflatoxins Alachlor Alcoholic beverages, when associated with alcohol abuse Aldrin All-trans retinoic acid Allyl chloride Delisted October 29, 1999 [Click here for the basis for delisting]
Alprazolam
Aminopterin
Type of Toxicity
SQE
FR FR LC
Amiodarone hydrochloride Amitraz Amitrole Amoxapine Amsacrine tert-Amyl methyl ether Anabolic steroids Analgesic mixtures containing Phenacetin cancer Androstenedione cancer Angiotensin converting enzyme (ACE) inhibitors developmental
SQE FR LC LC
FR LC
-2-
Date Listed
1-Oct-92
Chemical Aniline Aniline hydrochloride o -Anisidine o -Anisidine hydrochloride Anisindione Anthraquinone Antimony oxide (Antimony trioxide) Aramite Areca nut Aristolochic acids
Type of Toxicity cancer cancer cancer cancer developmental cancer cancer cancer cancer cancer
AB
SQE
----
27-Feb-87 1-May-97
LC
1332-21-4
27-Feb-87
SQE
50-78-2 29122-68-7 492-80-8 34031-32-8 71751-41-2 320-67-2 115-02-6 446-86-6 446-86-6 103-33-3
1-Jul-90 26-Aug-97 1-Jul-87 29-Jan-99 3-Dec-10 1-Jan-92 1-Jul-87 27-Feb-87 1-Sep-96 1-Jan-90
--5534-09-8
1-Oct-92 15-May-98
AB
AB SQE LC LC
LC
cancer
Aspirin (NOTE: It is especially important not to use aspirin during the last three months of pregnancy, unless specifically directed to do so by a physician because it may cause problems in the unborn child or complications during delivery.) Atenolol Auramine Auranofin Avermectin B1 (Abamectin) Azacitidine Azaserine Azathioprine Azathioprine Azobenzene
developmental, female developmental cancer developmental developmental cancer cancer cancer developmental cancer
Benomyl Benthiavalicarb-isopropyl Benz[a]anthracene
developmental developmental developmental, male cancer cancer
Benzene
cancer -3-
Date Listed 1-Jan-90 15-May-98 1-Jul-87 1-Jul-87 1-Oct-92 28-Sep-07 1-Oct-90 1-Jul-87 3-Feb-06 9-Jul-04
SQE SQE FR
Asbestos
CAS No. 62-53-3 142-04-1 90-04-0 134-29-2 117-37-3 84-65-1 1309-64-4 140-57-8 -----
AB
Arsenic (inorganic arsenic compounds) cancer Arsenic (inorganic oxides) developmental
Barbiturates Beclomethasone dipropionate
Listing Mechanism
FR
SQE FR AB
AB SQE LC FR AB FR FR
SQE SQE
17804-35-2 177406-68-7 56-55-3
LC
71-43-2
AB
1-Jul-91 1-Jul-08 1-Jul-87 27-Feb-87
Chemical
Type of Toxicity
Listing Mechanism
CAS No.
Date Listed
developmental, male cancer cancer developmental cancer cancer cancer cancer cancer cancer developmental cancer cancer
LC FR FR SQE SQE SQE AB SQE SQE FR AB SQE
71-43-2 92-87-5 ----205-99-2 205-82-3 207-08-9 271-89-6 50-32-8 98-07-7 5411-22-3 100-44-7 1694-09-3
Beryllium and beryllium compounds Beryllium Beryllium oxide Beryllium sulfate Betel quid with tobacco Betel quid without tobacco
cancer
SQE
---
1-Oct-87
cancer cancer
AB LC
-----
1-Jan-90 3-Feb-06
2,2-Bis(bromomethyl)-1,3-propanediol Bis(2-chloroethyl)ether N,N-Bis(2-chloroethyl)-2naphthylamine (Chlornapazine) Bischloroethyl nitrosourea (BCNU) (Carmustine) Bischloroethyl nitrosourea (BCNU) (Carmustine) Bis(chloromethyl)ether Bis(2-chloro-1-methylethyl)ether, technical grade Bitumens, extracts of steam-refined and air refined Bracken fern Bromacil lithium salt Bromacil lithium salt Bromate Bromochloroacetic acid Bromodichloromethane Bromoethane Bromoform
cancer cancer
AB SQE
3296-90-0 111-44-4
1-May-96 1-Apr-88
cancer
LC
494-03-1
27-Feb-87
cancer
SQE
154-93-8
1-Jul-87
FR LC
154-93-8 542-88-1
1-Jul-90 27-Feb-87
SQE
---
29-Oct-99
AB AB
AB
----53404-19-6 53404-19-6 15541-45-4 5589-96-8 75-27-4 74-96-4 75-25-2
1-Jan-90 1-Jan-90 18-May-99 17-Jan-03 31-May-02 6-Apr-10 1-Jan-90 22-Dec-00 1-Apr-91
AB
106-94-5
Benzene Benzidine [and its salts] Benzidine-based dyes Benzodiazepines Benzo[b]fluoranthene Benzo[j]fluoranthene Benzo[k]fluoranthene Benzofuran Benzo[a]pyrene Benzotrichloride Benzphetamine hydrochloride Benzyl chloride Benzyl violet 4B
1-Bromopropane (1-BP)
developmental cancer cancer cancer cancer developmental male cancer cancer cancer cancer cancer developmental, female, male -4-
SQE
AB SQE AB AB
AB AB
26-Dec-97 27-Feb-87 1-Oct-92 1-Oct-92 1-Jul-87 1-Jul-87 1-Jul-87 1-Oct-90 1-Jul-87 1-Jul-87 1-Apr-90 1-Jan-90 1-Jul-87
7-Dec-04
Chemical 2-Bromopropane (2-BP) Bromoxynil Bromoxynil octanoate Butabarbital sodium 1,3-Butadiene
Type of Toxicity
CAS No.
Date Listed
FR SQE
75-26-3 1689-84-5 1689-99-2 143-81-7 106-99-0
31-May-05 1-Oct-90 18-May-99 1-Oct-92 1-Apr-88
developmental, female, male
AB
106-99-0
16-Apr-04
cancer
LC
55-98-1
27-Feb-87
developmental cancer developmental male cancer
SQE AB
SQE
55-98-1 25013-16-5 85-68-7 2426-08-6 3068-88-0
1-Jan-89 1-Jan-90 2-Dec-05 7-Aug-09 1-Jul-87
AB
75-60-5
1-May-96
Cium
cancer developmental, male
SQE
---
1-May-97
Cium and cium compounds
cancer
SQE
---
1-Oct-87
cancer cancer cancer developmental cancer developmental, male cancer
AB SQE AB
331-39-5 2425-06-1 133-06-2 298-46-4 63-25-2
1-Oct-94 1-Oct-88 1-Jan-90 29-Jan-99 5-Feb-10
AB
63-25-2 86-74-8
7-Aug-09 1-May-96
cancer developmental, female, male developmental cancer cancer developmental cancer cancer
AB
1333-86-4
21-Feb-03
SQE SQE SQE AB FR SQE AB
75-15-0 630-08-0 56-23-5 --41575-94-4 60391-92-6 120-80-9
1-Jul-89 1-Jul-89 1-Oct-87 1-Jan-90 1-Jul-90 25-Jan-02 15-Jul-03
AB
---
1,3-Butadiene 1,4-Butanediol dimethanesulfonate (Busulfan) 1,4-Butanediol dimethanesulfonate (Busulfan) Butylated hydroxyanisole Butyl benzyl phthalate (BBP) n-Butyl glycidyl ether beta-Butyrolactone Cacodylic acid
Cium Caffeic acid Captafol Captan Carbamazepine Carbaryl Carbaryl Carbazole Carbon black (airborne, unbound particles of respirable size) Carbon disulfide Carbon monoxide Carbon tetrachloride Carbon-black extracts Carboplatin N-Carboxymethyl-N-nitrosourea Catechol Ceramic fibers (airborne particles of respirable size)
female, male developmental developmental developmental cancer
Listing Mechanism AB
FR AB
AB LC
cancer -5-
FR AB LC
1-Jul-90
Chemical Certain combined chemotherapy for lymphomas Chenodiol Chlorambucil Chlorambucil Chloramphenicol Chlorcyclizine hydrochloride Chlordane Chlordecone (Kepone) Chlordecone (Kepone) Chlordiazepoxide Chlordiazepoxide hydrochloride Chlordimeform Chlorendic acid Chlorinated paraffins (Average chain length, C12;approximately 60 percent chlorine by weight) p -Chloroaniline p -Chloroaniline hydrochloride Chlorodibromomethane Delisted October 29, 1999 [Click here for the basis for delisting]
Chloroethane (Ethyl chloride) 1-(2-Chloroethyl)-3-cyclohexyl-1nitrosourea (CCNU) (Lomustine) 1-(2-Chloroethyl)-3-cyclohexyl-1nitrosourea (CCNU) (Lomustine) 1-(2-Chloroethyl)-3-(4methylcyclohexyl)-1-nitrosourea (Methyl-CCNU)
Chloroform Chloroform Chloromethyl methyl ether (technical grade) 3-Chloro-2-methylpropene 1-Chloro-4-nitrobenzene 4-Chloro-o -phenylenediamine Chloroprene 2-Chloropropionic acid Chlorothalonil p -Chloro-o -toluidine
Listing Mechanism
CAS No.
cancer developmental cancer developmental cancer developmental cancer cancer developmental developmental developmental cancer cancer
LC FR LC SQE LC FR SQE SQE SQE FR FR SQE SQE
--474-25-9 305-03-3 305-03-3 56-75-7 1620-21-9 57-74-9 143-50-0 143-50-0 58-25-3 438-41-5 6164-98-3 115-28-6
27-Feb-87 1-Apr-90 27-Feb-87 1-Jan-89 1-Oct-89 1-Jul-87 1-Jul-88 1-Jan-88 1-Jan-89 1-Jan-92 1-Jan-92 1-Jan-89 1-Jul-89
cancer cancer cancer
SQE AB AB
108171-26-2 106-47-8 20265-96-7
1-Jul-89 1-Oct-94 15-May-98
cancer cancer
AB AB
124-48-1 75-00-3
1-Jan-90 1-Jul-90
cancer
SQE
13010-47-4
1-Jan-88
FR
13010-47-4
1-Jul-90
cancer
SQE
13909-09-6
1-Oct-88
cancer developmental
SQE
67-66-3 67-66-3
1-Oct-87 7-Aug-09
cancer cancer cancer cancer cancer male cancer cancer
LC SQE
107-30-2 563-47-3 100-00-5 95-83-0 126-99-8 598-78-7 1897-45-6 95-69-2
27-Feb-87 1-Jul-89 29-Oct-99 1-Jan-88 2-Jun-00 7-Aug-09 1-Jan-89 1-Jan-90
Type of Toxicity
developmental
LC
SQE
SQE AB LC
SQE AB
-6-
Date Listed
Chemical
Type of Toxicity
p- Chloro-o -toluidine, strong acid salts of cancer p- Chloro-o -toluidine, hydrochloride 5-Chloro-o -toluidine and its strong acid salts Chlorotrianisene Chlorozotocin
cancer cancer cancer
Chlorsulfuron [Click here for the basis for removal of male reproductive toxicity endpoint]
developmental, female, male
Chromium (hexavalent compounds) Chromium (hexavalent compounds) Chrysene C.I. Acid Red 114 C.I. Basic Red 9 monohydrochloride C.I. Direct Blue 15 C.I. Direct Blue 218 C.I. Solvent Yellow 14 Ciclosporin (Cyclosporin A; Cyclosporine)
Cidofovir Cinnamyl anthranilate Cisplatin Citrus Red No. 2 Cladribine Clarithromycin Clobetasol propionate Clofibrate Clomiphene citrate Clorazepate dipotassium Cobalt metal powder Cobalt [II] oxide Cobalt sulfate Cobalt sulfate heptahydrate Cocaine Codeine phosphate Coke oven emissions
cancer developmental, female, male cancer cancer cancer cancer cancer cancer cancer cancer, developmental, female, male cancer cancer cancer developmental developmental developmental, female cancer developmental developmental cancer cancer cancer cancer developmental, female developmental cancer
-7-
Listing Mechanism
CAS No.
AB
---
15-May-98
SQE
FR AB
--569-57-3 54749-90-5
24-Oct-97 1-Sep-96 1-Jan-92
AB
64902-72-3
14-May-99
LC
---
27-Feb-87
SQE
--218-01-9 6459-94-5 569-61-9 2429-74-5 28407-37-6 842-07-9 59865-13-3; 79217-60-0
19-Dec-08 1-Jan-90 1-Jul-92 1-Jul-89 26-Aug-97 26-Aug-97 15-May-98
113852-37-2 87-29-6 15663-27-1 6358-53-8 4291-63-8 81103-11-9
29-Jan-99 1-Jul-89 1-Oct-88 1-Oct-89 1-Sep-96 1-May-97
25122-46-7 637-07-0 50-41-9 57109-90-7 7440-48-4 1307-96-6 10124-43-3 10026-24-1 50-36-2 52-28-8 ---
15-May-98 1-Sep-96 1-Apr-90 1-Oct-92 1-Jul-92 1-Jul-92 20-May-05 2-Jun-00 1-Jul-89 15-May-98 27-Feb-87
AB AB SQE AB AB AB
AB
FR
SQE SQE LC FR FR FR
FR FR FR AB AB LC AB
SQE FR
LC
Date Listed
1-Jan-92
Chemical
Colchicine Conjugated estrogens Conjugated estrogens Creosotes p -Cresidine Cumene Cupferron Cyanazine Cycasin Cycloate Cyclohexanol Delisted January 25, 2002 [Click here for the basis for delisting]
Type of Toxicity developmental, male cancer developmental cancer cancer cancer cancer developmental cancer developmental
Cycloheximide Cyclopenta[cd ]pyrene Cyclophosphamide (anhydrous)
male developmental cancer cancer
Cyclophosphamide (anhydrous) Cyclophosphamide (hydrated)
developmental, female, male cancer
Cyclophosphamide (hydrated) Cyhexatin Cytarabine Cytembena
developmental, female, male developmental developmental cancer
D&C Orange No. 17 D&C Red No. 8 D&C Red No. 9 D&C Red No. 19 Dacarbazine Dacarbazine Daminozide Danazol Dantron (Chrysazin; 1,8Dihydroxyanthraquinone) Daunomycin Daunorubicin hydrochloride 2,4-D butyric acid [Click here for the basis for the removal of developmental toxicity endpoint]
Listing Mechanism
FR LC FR SQE SQE AB
SQE FR SQE AB AB
FR LC
LC SQE developmental FR - female, male LC SQE developmental FR - female, male FR SQE AB
CAS No.
Date Listed
64-86-8 ------120-71-8 98-82-8 135-20-6 21725-46-2 14901-08-7 1134-23-2
1-Oct-92 27-Feb-87 1-Apr-90 1-Oct-88 1-Jan-88 6-Apr-10 1-Jan-88 1-Apr-90 1-Jan-88 19-Mar-99
108-93-0 66-81-9 27208-37-3 50-18-0
6-Nov-98 1-Jan-89 29-Apr-11 27-Feb-87
50-18-0 6055-19-2
1-Jan-89 27-Feb-87
6055-19-2 13121-70-5 147-94-4 21739-91-3
1-Jan-89 1-Jan-89 1-Jan-89 15-May-98 1-Jul-90 1-Oct-90 1-Jul-90 1-Jul-90 1-Jan-88 29-Jan-99 1-Jan-90 1-Apr-90
cancer cancer cancer cancer cancer developmental cancer developmental
AB AB AB AB SQE AB FR
3468-63-1 2092-56-0 5160-02-1 81-88-9 4342-03-4 4342-03-4 1596-84-5 17230-88-5
cancer cancer developmental
AB SQE FR
117-10-2 20830-81-3 23541-50-6
1-Jan-92 1-Jan-88 1-Jul-90
developmental, male
AB
94-82-6
18-Jun-99
FR
-8-
Chemical
Type of Toxicity
Listing Mechanism
CAS No.
Date Listed
DDD (Dichlorodiphenyldichloroethane)
cancer
SQE
72-54-8
1-Jan-89
DDE (Dichlorodiphenyldichloroethylene)
cancer
SQE
72-55-9
1-Jan-89
SQE
50-29-3
1-Oct-87
o,p'-DDT
cancer developmental, female, male
AB
789-02-6
15-May-98
p,p'-DDT DDVP (Dichlorvos)
developmental, female, male cancer
AB
SQE
50-29-3 62-73-7
15-May-98 1-Jan-89
AB
120-36-5
27-Apr-99
developmental cancer cancer cancer
FR LC FR SQE
64-73-3 613-35-4 615-05-4 39156-41-7
1-Jan-92 1-Oct-89 1-Oct-90 1-Jan-88
cancer cancer cancer developmental cancer developmental cancer cancer cancer cancer cancer cancer cancer cancer cancer cancer
SQE SQE AB FR
AB AB
101-80-4 95-80-7 --439-14-5 136-35-6 364-98-7 226-36-8 224-42-0 53-70-3 194-59-2 192-65-4 189-64-0 189-55-9 191-30-0 631-64-1 3252-43-5
1-Jan-88 1-Jan-88 1-Jan-90 1-Jan-92 20-May-05 27-Feb-01 1-Jan-88 1-Jan-88 1-Jan-88 1-Jan-88 1-Jan-88 1-Jan-88 1-Jan-88 1-Jan-88 17-Jun-08 3-May-11
FR
96-12-8
DDT (Dichlorodiphenyltrichloroethane)
2,4-DP (dichloroprop) Delisted January 25, 2002 [Click here for the basis for delisting] developmental
Demeclocycline hydrochloride (internal use) N,N'-Diacetylbenzidine 2,4-Diaminoanisole 2,4-Diaminoanisole sulfate 4,4'-Diaminodiphenyl ether (4,4'Oxydianiline) 2,4-Diaminotoluene Diaminotoluene (mixed) Diazepam Diazoaminobenzene Diazoxide Dibenz[a,h]acridine Dibenz[a,j]acridine Dibenz[a,h]anthracene 7H-Dibenzo[c,g]carbazole Dibenzo[a,e]pyrene Dibenzo[a,h]pyrene Dibenzo[a,i]pyrene Dibenzo[a,l]pyrene Dibromoacetic acid Dibromoacetonitrile
LC FR
SQE SQE SQE SQE SQE SQE SQE SQE
1,2-Dibromo-3-chloropropane (DB) cancer -9-
1-Jul-87
Chemical
Type of Toxicity
1,2-Dibromo-3-chloropropane (DB) male 2,3-Dibromo-1-propanol cancer Dichloroacetic acid cancer Dichloroacetic acid male p -Dichlorobenzene cancer 3,3'-Dichlorobenzidine cancer
Listing Mechanism
LC AB AB
CAS No.
Date Listed
SQE SQE
96-12-8 96-13-9 79-43-6 79-43-6 106-46-7 91-94-1
27-Feb-87 1-Oct-94 1-May-96 7-Aug-09 1-Jan-89 1-Oct-87
AB
612-83-9
15-May-98
AB
AB
72-55-9 764-41-0
30-Mar-10 1-Jan-90
LC
3,3'-Dichlorobenzidine dihydrochloride 1,1-Dichloro-2,2-bis(p chloropheny)ethylene (DDE) 1,4-Dichloro-2-butene 3,3'-Dichloro-4,4'-diamino-diphenyl ether 1,1-Dichloroethane
cancer developmental, male cancer cancer cancer
SQE AB
28434-86-8 75-34-3
1-Jan-88 1-Jan-90
Dichloromethane (Methylene chloride) Dichlorophene Dichlorphenamide Diclofop-methyl Diclofop methyl 1,2-Dichloropropane 1,3-Dichloro-2-propanol (1,3-D) 1,3-Dichloropropene Dicumarol Dieldrin Dienestrol Diepoxybutane Diesel engine exhaust Di(2-ethylhexyl)phthalate
cancer developmental developmental cancer developmental cancer cancer cancer developmental cancer cancer cancer cancer cancer
SQE
SQE FR SQE LC SQE AB SQE
75-09-2 97-23-4 120-97-8 51338-27-3 51338-27-3 78-87-5 96-23-1 542-75-6 66-76-2 60-57-1 84-17-3 1464-53-5 --117-81-7
1-Apr-88 27-Apr-99 27-Feb-01 6-Apr-10 5-Mar-99 1-Jan-90 8-Oct-10 1-Jan-89 1-Oct-92 1-Jul-88 1-Jan-90 1-Jan-88 1-Oct-90 1-Jan-88
Di(2-ethylhexyl)phthalate
developmental, male
AB
117-81-7
24-Oct-03
AB FR AB AB
AB SQE
- 10 -
Listing Mechanism
CAS No.
cancer cancer developmental cancer developmental, female male cancer developmental cancer cancer
SQE LC FR SQE
1615-80-1 56-53-1 56-53-1 64-67-5
1-Jan-88 27-Feb-87 1-Jul-87 1-Jan-88
FR LC
29-Jan-99 7-Aug-09 1-Jul-89 1-May-97 1-Jan-88 1-Apr-93
developmental developmental
AB FR
22494-42-4 2238-07-5 101-90-6 6190-39-2 94-58-6 2973-10-6 68515-49-1/ 26761-40-0 33286-22-5
cancer
SQE
119-90-4
1-Jan-88
cancer
AB
20325-40-0
1-Oct-90
cancer developmental cancer
AB LC
SQE
--127-19-5 60-11-7
cancer cancer
SQE AB
55738-54-0 57-97-6
1-Jan-88 1-Jan-90
3,3'-Dimethylbenzidine (ortho-Tolidine) cancer
SQE
119-93-7
1-Jan-88
3,3'-Dimethylbenzidine dihydrochloride cancer
AB
612-82-8
1-Apr-92
3,3'-Dimethylbenzidine-based dyes metabolized to 3,3'-dimethylbenzidine cancer
AB
---
Chemical
1,2-Diethylhydrazine Diethylstilbestrol (DES) Diethylstilbestrol (DES) Diethyl sulfate Diflunisal Diglycidyl ether Diglycidyl resorcinol ether (DGRE) Dihydroergotamine mesylate Dihydrosafrole Diisopropyl sulfate Di-isodecyl phthalate (DIDP) Diltiazem hydrochloride 3,3'-Dimethoxybenzidine (o Dianisidine) 3,3'-Dimethoxybenzidine dihydrochloride 3,3'-Dimethoxybenzidine-based dyes metabolized to 3,3'dimethoxybenzidine N,N-Dimethylacetamide 4-Dimethylaminoazobenzene trans -2-[(Dimethylamino)methylimino]5-[2-(5-nitro-2-furyl)vinyl]-1,3,4oxadiazole 7,12-Dimethylbenz(a)anthracene
Type of Toxicity
- 11 -
SQE FR
SQE AB
Date Listed
20-Apr-07 27-Feb-01
11-Jun-04 21-May-10 1-Jan-88
11-Jun-04
Chemical Dimethylcarbamoyl chloride 1,1-Dimethylhydrazine (UDMH) 1,2-Dimethylhydrazine Dimethyl sulfate Dimethylvinylchloride Di-n -butyl phthalate (DBP) Di-n -hexyl phthalate (DnHP) m -Dinitrobenzene o -Dinitrobenzene p -Dinitrobenzene 3,7-Dinitrofluoranthene 3,9-Dinitrofluoranthene 1,6-Dinitropyrene 1,8-Dinitropyrene 2,4-Dinitrotoluene 2,4-Dinitrotoluene 2,6-Dinitrotoluene 2,6-Dinitrotoluene Dinitrotoluene (technical grade) Dinitrotoluene mixture, 2,4-/2,6Dinocap Dinoseb Di-n -propyl isocinchomeronate (MGK Repellent 326) 1,4-Dioxane Diphenylhydantoin (Phenytoin) Diphenylhydantoin (Phenytoin) Diphenylhydantoin (Phenytoin), sodium salt Direct Black 38 (technical grade) Direct Blue 6 (technical grade) Direct Brown 95 (technical grade)
Listing Mechanism
CAS No.
cancer cancer cancer cancer cancer developmental, female, male female, male male male male cancer cancer cancer cancer cancer male cancer male female, male cancer developmental developmental, male cancer cancer cancer developmental
SQE LC SQE SQE SQE
79-44-7 57-14-7 540-73-8 77-78-1 513-37-1
AB AB
AB FR FR AB SQE SQE SQE
84-74-2 84-75-3 99-65-0 528-29-0 100-25-4 105735-71-5 22506-53-2 42397-64-8 42397-65-9 121-14-2 121-14-2 606-20-2 606-20-2 ----39300-45-3 88-85-7 136-45-8 123-91-1 57-41-0 57-41-0
2-Dec-05 2-Dec-05 1-Jul-90 1-Jul-90 1-Jul-90 26-Aug-97 26-Aug-97 1-Oct-90 1-Oct-90 1-Jul-88 20-Aug-99 1-Jul-95 20-Aug-99 20-Aug-99 1-May-96 1-Apr-90 1-Jan-89 1-May-96 1-Jan-88 1-Jan-88 1-Jul-87
cancer cancer cancer cancer
SQE SQE SQE SQE
630-93-3 1937-37-7 2602-46-2 16071-86-6
1-Jan-88 1-Jan-88 1-Jan-88 1-Oct-88
AB AB
138-93-2 2475-45-8 330-54-1
30-Mar-99 1-Oct-90 31-May-02
SQE
25316-40-9
1-Jul-87
FR
25316-40-9 564-25-0
29-Jan-99 1-Jul-90
Type of Toxicity
Disodium cyanodithioimidocarbonate Disperse Blue 1 Diuron Doxorubicin hydrochloride (Adriamycin)
developmental cancer cancer
Doxorubicin hydrochloride (Adriamycin) Doxycycline (internal use)
developmental, male developmental
AB AB AB AB AB
AB AB SQE AB
SQE AB AB
AB
cancer
- 12 -
FR
Date Listed 1-Jan-88 1-Oct-89 1-Jan-88 1-Jan-88 1-Jul-89
Chemical
Type of Toxicity
Listing Mechanism
CAS No.
Date Listed
Doxycycline calcium (internal use) Doxycycline hyclate (internal use) Doxycycline monohydrate (internal use)
developmental developmental
FR FR
94088-85-4 24390-14-5
1-Jan-92 1-Oct-91
developmental
FR
17086-28-1
1-Oct-91
Endrin
developmental
AB
72-20-8
15-May-98
Environmental tobacco smoke (ETS) Epichlorohydrin Epichlorohydrin Epoxiconazole Ergotamine tartrate
developmental cancer male cancer developmental
SQE
9-Jun-06 1-Oct-87 1-Sep-96 15-Apr-11 1-Apr-90
Erionite Estradiol 17B Estragole Estrogens, steroidal Estrogen-progestogen (combined) used as menopausal therapy Estrone
cancer cancer cancer cancer
--106-89-8 106-89-8 135319-73-2 379-79-3 12510-42-8; 66733-21-9 50-28-2 140-67-0 ---
1-Oct-88 1-Jan-88 29-Oct-99 19-Aug-05
--53-16-7
4-Nov-11 1-Jan-88
SQE SQE
7280-37-7 --57-63-6 536-33-4 13194-48-4 140-88-5 ---
26-Aug-97 29-Apr-11 1-Jan-88 26-Aug-97 27-Feb-01 1-Jul-89 1-Oct-87
SQE AB AB
FR SQE SQE SQE LC
Estropipate Ethanol in alcoholic beverages Ethinylestradiol Ethionamide Ethoprop Ethyl acrylate Ethyl alcohol in alcoholic beverages
cancer cancer cancer, developmental cancer cancer developmental cancer cancer developmental
Ethylbenzene Ethyl-tert-butyl ether
cancer male
AB LC
100-41-4 637-92-3
11-Jun-04 18-Dec-09
Ethyl dipropylthiocarbamate Ethyl-4,4'-dichlorobenzilate
developmental cancer
AB
AB
759-94-4 510-15-6
27-Apr-99 1-Jan-90
Ethylene dibromide
cancer developmental, male
FR
106-93-4
1-Jul-87
AB
106-93-4
15-May-98
cancer
SQE
107-06-2
1-Oct-87
developmental, male
SQE
110-80-5
1-Jan-89
Ethylene dibromide Ethylene dichloride (1,2Dichloroethane)
Ethylene glycol monoethyl ether
LC
SQE FR LC
SQE FR AB
- 13 -
Chemical
Ethylene glycol monoethyl ether acetate Ethylene glycol monomethyl ether Ethylene glycol monomethyl ether acetate Ethyleneimine Ethylene oxide Ethylene oxide Ethylene oxide Ethylene thiourea Ethylene thiourea 2-Ethylhexanoic acid Ethyl methanesulfonate
Type of Toxicity
developmental, male developmental, male developmental, male cancer cancer female developmental, male cancer developmental developmental cancer developmental, female cancer developmental
Etodolac Etoposide Etoposide Etoposide in combination with cisplatin and bleomycin cancer Etretinate developmental Fenoxaprop ethyl Fenoxycarb Filgrastim Fluazifop butyl Flunisolide Fluorouracil Fluoxymesterone Flurazepam hydrochloride Flurbiprofen Flutamide Fluticasone propionate Fluvalinate Folpet Formaldehyde (gas) 2-(2-Formylhydrazino)-4-(5-nitro-2furyl)thiazole Fumonisin B1 Furan
Listing Mechanism
CAS No.
AB
111-15-9
1-Jan-93
SQE
109-86-4
1-Jan-89
AB SQE FR LC
110-49-6 151-56-4 75-21-8 75-21-8
1-Jan-93 1-Jan-88 1-Jul-87 27-Feb-87
LC
75-21-8 96-45-7 96-45-7 149-57-5 62-50-0
7-Aug-09 1-Jan-88 1-Jan-93 7-Aug-09 1-Jan-88
41340-25-4 33419-42-0 33419-42-0
20-Aug-99 4-Nov-11 1-Jul-90
SQE
--54350-48-0
4-Nov-11 1-Jul-87
AB AB FR AB
66441-23-4 72490-01-8 121181-53-1 69806-50-4
26-Mar-99 2-Jun-00 27-Feb-01 6-Nov-98
FR
3385-03-3 51-21-8 76-43-7 1172-18-5
15-May-98 1-Jan-89 1-Apr-90 1-Oct-92
5104-49-4 13311-84-7 80474-14-2 69409-94-5 133-07-3 50-00-0
20-Aug-99 1-Jul-90 15-May-98 6-Nov-98 1-Jan-89 1-Jan-88 1-Jan-88 14-Nov-03
AB SQE LC
SQE FR LC
FR LC
developmental cancer developmental developmental developmental, female developmental developmental developmental developmental, female developmental developmental developmental cancer cancer
SQE FR FR FR
FR FR AB
SQE SQE
cancer cancer
SQE AB
3570-75-0 116355-83-0
cancer
AB
110-00-9
- 14 -
Date Listed
1-Oct-93
Chemical
Listing Mechanism
CAS No.
AB AB SQE
67-45-8 60568-05-0 79748-81-5
1-Jan-90 1-Jan-90 1-Jul-95
LC
1303-00-0
1-Aug-08
FR
82410-32-0
26-Aug-97
FR
107910-75-8
26-Aug-97
cancer cancer female, male
AB FR FR
--25812-30-0 25812-30-0
1-Oct-90 22-Dec-00 20-Aug-99
cancer
AB
---
1-Jul-90
AB
67730-11-4
1-Jan-90
AB SQE AB
67730-10-3 765-34-4 556-52-5
1-Jan-90 1-Jan-88 1-Jul-90
FR
AB
65807-02-5 126-07-8
26-Aug-97 1-Jan-90
SQE
16568-02-8
1-Jan-88
FR
23092-17-3 66852-54-8
1-Jul-90 20-Aug-99
52-86-8 151-67-7 2784-94-3 76-44-8 76-44-8 1024-57-3
29-Jan-99 1-Sep-96 1-Jul-89 1-Jul-88 20-Aug-99 1-Jul-88
--118-74-1 118-74-1 87-68-3
9-Jul-04 1-Oct-87 1-Jan-89 3-May-11
Type of Toxicity
Furazolidone Furmecyclox Fusarin C
cancer cancer cancer
Gallium arsenide
cancer cancer, developmental, male developmental, male
Ganciclovir Ganciclovir sodium Gasoline engine exhaust (condensates/extracts) Gemfibrozil Gemfibrozil Glass wool fibers (inhalable and biopersistent)
Glu-P-1 (2-Amino-6-methyldipyrido[1,2a:3',2'-d]imidazole) cancer Glu-P-2 (2-Aminodipyrido[1,2-a:3',2'd]imidazole) cancer Glycidaldehyde cancer Glycidol cancer developmental, Goserelin acetate female, male Griseofulvin cancer Gyromitrin (Acetaldehyde methylformylhydrazone) cancer Halazepam Halobetasol propionate Haloperidol Halothane HC Blue 1 Heptachlor Heptachlor Heptachlor epoxide Herbal remedies containing plant species of the genus Aristolochia Hexachlorobenzene Hexachlorobenzene Hexachlorobutadiene
developmental developmental developmental, female developmental cancer cancer developmental cancer cancer cancer developmental cancer
FR FR
FR SQE SQE AB
SQE LC
SQE SQE AB
- 15 -
Date Listed
Chemical Hexachlorocyclohexane (technical grade) Hexachlorocyclohexane (alpha isomer) Hexachlorocyclohexane (beta isomer) Hexachlorocyclohexane (gamma isomer) Hexachlorodibenzodioxin Hexachloroethane 2,4-Hexadienal (89% trans, trans isomer; 11% cis, trans isomer) Hexafluoroacetone Hexamethylphosphoramide Hexamethylphosphoramide Histrelin acetate Hydramethylnon Hydrazine Hydrazine sulfate Hydrazobenzene (1,2Diphenylhydrazine) 1-Hydroxyanthraquinone Hydroxyurea
Idarubicin hydrochloride Ifosfamide Iodine-131 Imazalil Indeno [1,2,3-cd]pyrene Indium phosphide IQ (2-Amino-3-methylimidazo[4,5-f] quinoline) Iprodione
Iprovalicarb Iron dextran complex Isobutyl nitrite Isoprene Isosafrole Delisted December 8, 2006 [Click here for the basis for delisting]
Isotretinoin
Listing Mechanism
CAS No.
cancer
SQE
---
1-Oct-87
cancer cancer
SQE AB
34465-46- 8 67-72-1
1-Apr-88 1-Jul-90
AB LC
--684-16-2 680-31-9 680-31-9 ---
Type of Toxicity
cancer male cancer male developmental developmental, male cancer cancer cancer cancer developmental
SQE AB FR AB
SQE SQE SQE
67485-29-4 302-01-2 10034-93-2
Date Listed
4-Mar-05 1-Aug-08 1-Jan-88 1-Oct-94 15-May-98 5-Mar-99 1-Jan-88 1-Jan-88
122-66-7 129-43-1 127-07-1
1-Jan-88 27-May-05 1-May-97
AB
57852-57-0 3778-73-2 10043-66-0 35554-44-0 193-39-5 22398-80-7
20-Aug-99 1-Jul-90 1-Jan-89 20-May-11 1-Jan-88 27-Feb-01
cancer cancer
AB AB
76180-96-6 36734-19-7
1-Apr-90 1-May-96
cancer cancer cancer cancer
AB
SQE AB AB
140923-17-7 & 140923-25-7 9004-66-4 542-56-3 78-79-5
1-Jun-07 1-Jan-88 1-May-96 1-May-96
cancer developmental
LC SQE
120-58-1 4759-48-2
1-Oct-89 1-Jul-87
LC FR
developmental, male developmental developmental cancer cancer cancer
- 16 -
FR
FR SQE AB
SQE
Chemical
Type of Toxicity
Listing Mechanism
CAS No.
Date Listed
Isoxaflutole
cancer
AB
141112-29-0
22-Dec-00
Kresoxim-methyl
cancer
AB
143390-89-0
3-Feb-12
Lactofen Lasiocarpine
cancer cancer developmental, female, male cancer
SQE SQE
77501-63-4 303-34-4
1-Jan-89 1-Apr-88
LC AB
-----
27-Feb-87 1-Oct-92
cancer cancer cancer cancer developmental, female, male developmental female
SQE SQE LC LC
301-04-2 7446-27-7 1335-32-6 ---
1-Jan-88 1-Apr-88 1-Oct-89 29-Apr-11
FR FR FR
74381-53-6 59-92-7 797-63-7
26-Aug-97 29-Jan-99 15-May-98
cancer developmental developmental developmental developmental developmental cancer
LC
--330-55-2 554-13-2 919-16-4 846-49-1 75330-75-5 52-76-6
1-Oct-89 19-Mar-99 1-Jan-91 1-Jan-91 1-Jul-90 1-Oct-92 27-Feb-01
24382-04-5 8018-01-7 12427-38-2 ---
29-Apr-11 1-Jan-90 1-Jan-90 19-Jun-09 1-Jan-90 20-Aug-99 1-Jan-90 1-Apr-90 1-Jan-91
Lead Lead and lead compounds Lead Lead acetate Lead phosphate Lead subacetate Leather dust Leuprolide acetate Levodopa Levonorgestrel implants Lindane and other hexachlorocyclohexane isomers Linuron Lithium carbonate Lithium citrate Lorazepam Lovastatin Lynestrenol Malonaldehyde, sodium salt Mancozeb Maneb Marijuana smoke Me-A-alpha-C (2-Amino-3-methyl-9Hpyrido[2,3-b]indole) Mebendazole Medroxyprogesterone acetate Medroxyprogesterone acetate Megestrol acetate MeIQ (2-Amino-3,4dimethylimidazo[4,5-f]quinoline) MeIQx (2-Amino-3,8dimethylimidazo[4,5-f]quinoxaline) Melphalan Melphalan Menotropins
AB
FR FR FR FR AB
cancer cancer cancer cancer
AB
AB AB SQE
cancer developmental cancer developmental developmental
AB AB FR FR
68006-83-7 31431-39-7 71-58-9 71-58-9 595-33-5
cancer
AB
77094-11-2
1-Oct-94
cancer cancer developmental developmental
AB LC FR FR
77500-04-0 148-82-3 148-82-3 9002-68-0
1-Oct-94 27-Feb-87 1-Jul-90 1-Apr-90
FR
- 17 -
Chemical Mepanipyrim Meprobamate Mercaptopurine Mercury and mercury compounds Merphalan Mestranol Metam potassium Methacycline hydrochloride Metham sodium Metham sodium Methazole Methimazole Methotrexate Methotrexate sodium 5-Methoxypsoralen with ultraviolet A therapy 8-Methoxypsoralen with ultraviolet A therapy 2-Methylaziridine (Propyleneimine) Methylazoxymethanol Methylazoxymethanol acetate Methyl bromide, as a structural fumigant Methyl carbamate Methyl chloride Methyl chloride 3-Methylcholanthrene 5-Methylchrysene 4,4'-Methylene bis(2-chloroaniline) 4,4'-Methylene bis(N,Ndimethyl)benzenamine 4,4'-Methylene bis(2-methylaniline) 4,4'-Methylenedianiline
Type of Toxicity cancer developmental developmental developmental cancer cancer cancer developmental cancer developmental developmental developmental developmental developmental
Listing Mechanism
CAS No.
Date Listed
FR SQE FR
110235-47-7 57-53-4 6112-76-1 --531-76-0 72-33-3 137-41-7 3963-95-9 137-42-8 137-42-8 20354-26-1 60-56-0 59-05-2 15475-56-6
cancer
SQE
484-20-8
1-Oct-88
cancer cancer cancer cancer
LC SQE SQE SQE
298-81-7 75-55-8 590-96-5 592-62-1
27-Feb-87 1-Jan-88 1-Apr-88 1-Apr-88
FR
1-Jan-93 15-May-98 10-Mar-00 7-Aug-09 1-Jan-90 1-Apr-88 1-Jul-87 1-Oct-89 1-Apr-88 1-Jan-88
AB
FR FR AB SQE SQE AB
FR AB AB AB
1-Jul-08 1-Jan-92 1-Jul-90 1-Jul-90 1-Apr-88 1-Apr-88 31-Dec-10 1-Jan-91 6-Nov-98 15-May-98 1-Dec-99 1-Jul-90 1-Jan-89 1-Apr-90
developmental cancer developmental male cancer cancer cancer
AB SQE FR
74-83-9 598-55-0 74-87-3 74-87-3 56-49-5 3697-24-3 101-14-4
cancer cancer cancer
LC SQE SQE
101-61-1 838-88-0 101-77-9
4,4'-Methylenedianiline dihydrochloride cancer Methyleugenol cancer Methylhydrazine and its salts cancer
SQE
13552-44-8 93-15-2 ---
1-Jan-88 16-Nov-01 1-Jul-92
822-36-6 74-88-4 108-10-1
7-Jan-11 1-Apr-88 4-Nov-11
Methylhydrazine Methylhydrazine sulfate 4-Methylimidazole Methyl iodide Methyl isobutyl ketone
AB AB LC
AB
AB
cancer cancer cancer
AB
SQE LC - 18 -
Chemical
Methyl isocyanate (MIC)
Type of Toxicity developmental, female
Listing Mechanism
CAS No.
SQE
624-83-9
12-Nov-10
LC
17-Feb-12 1-Jul-87 1-May-96 1-Apr-88 7-Aug-09
Date Listed
Methyl isopropyl ketone Methyl mercury Methylmercury compounds Methyl methanesulfonate Methyl n-butyl ketone 2-Methyl-1-nitroanthraquinone (of uncertain purity)
developmental developmental cancer cancer male
SQE AB SQE LC
563-80-4 ----66-27-3 591-78-6
cancer
SQE
129-15-7
1-Apr-88
N-Methyl-N'-nitro-N-nitrosoguanidine N-Methylolacrylamide
cancer cancer
SQE AB
70-25-7 924-42-5
1-Apr-88 1-Jul-90
N-Methylpyrrolidone
developmental
AB
872-50-4
15-Jun-01
α-Methyl styrene Methyltestosterone Methylthiouracil Metiram Metiram Metronidazole Michler's ketone Midazolam hydrochloride Minocycline hydrochloride (internal use) Mirex Misoprostol Mitomycin C Mitoxantrone hydrochloride
female developmental cancer cancer developmental cancer cancer developmental
LC
SQE SQE FR
98-83-9 58-18-4 56-04-2 9006-42-2 9006-42-2 443-48-1 90-94-8 59467-96-8
29-Jul-11 1-Apr-90 1-Oct-89 1-Jan-90 30-Mar-99 1-Jan-88 1-Jan-88 1-Jul-90
FR SQE FR SQE FR
13614-98-7 2385-85-5 59122-46-2 50-07-7 70476-82-3
1-Jan-92 1-Jan-88 1-Apr-90 1-Apr-88 1-Jul-90
AB
2212-67-1
11-Dec-09
cancer cancer
AB AB
71526-07-3 121776-33-8
22-Mar-11 22-Mar-11
cancer cancer
SQE
SQE
96-24-2 315-22-0
8-Oct-10 1-Apr-88
LC
113803-47-7
4-Nov-11
Molinate MON 4660 (dichloroacetyl-1-oxa-4azaspiro(4,5)-decane MON 13900 (furilazole) 3-Monochloropropane-1,2-diol (3MCDP) Monocrotaline
FR LC AB AB
developmental cancer developmental cancer developmental developmental, female, male
MOPP (vincristine-prednisone-nitrogen mustard-procarbazine mixture) cancer
- 19 -
Listing Mechanism
CAS No.
cancer cancer
SQE LC
139-91-3 505-60-2
1-Apr-88 27-Feb-87
SQE
77439-76-0
22-Dec-00
Myclobutanil
cancer developmental, male
AB
88671-89-0
16-Apr-99
Nabam Nafarelin acetate Nafenopin Nalidixic acid Naphthalene 1-Naphthylamine 2-Naphthylamine Neomycin sulfate (internal use) Netilmicin sulfate Nickel (Metallic) Nickel acetate Nickel carbonate Nickel carbonyl Nickel carbonyl Nickel compounds
developmental developmental cancer cancer cancer cancer cancer developmental developmental cancer cancer cancer cancer developmental cancer
AB
30-Mar-99 1-Apr-90 1-Apr-88 15-May-98 19-Apr-02 1-Oct-89 27-Feb-87 1-Oct-92 1-Jul-90 1-Oct-89 1-Oct-89 1-Oct-89 1-Oct-87 1-Sep-96 7-May-04
Nickel hydroxide Nickelocene Nickel oxide Nickel refinery dust from the pyrometallurgical process Nickel subsulfide Nicotine
cancer cancer cancer
LC LC LC
142-59-6 86220-42-0 3771-19-5 389-08-2 91-20-3 134-32-7 91-59-8 1405-10-3 56391-57-2 7440-02-0 373-02-4 3333-67-3 13463-39-3 13463-39-3 --12054-48-7; 12125-56-3 1271-28-9 1313-99-1
cancer cancer developmental developmental, female, male developmental cancer cancer developmental cancer
SQE SQE FR
--12035-72-2 54-11-5
1-Oct-87 1-Oct-87 1-Apr-90
FR FR
SQE
21829-25-4 66085-59-4 61-57-4 1929-82-4 1929-82-4 139-13-9
29-Jan-99 24-Apr-01 1-Apr-88 5-Oct-05 30-Mar-99 1-Jan-88
cancer cancer
SQE SQE
18662-53-8 602-87-9
1-Apr-89 1-Apr-88
LC
99-59-2
1-Oct-89
Chemical 5-(Morpholinomethyl)-3-[(5nitrofurfurylidene)-amino]-2oxazolidinone Mustard Gas MX (3-chloro-4-dichloromethyl-5hydroxy-2(5H)-furanone)
Nifedipine Nimodipine Niridazole Nitrapyrin Nitrapyrin Nitrilotriacetic acid Nitrilotriacetic acid, trisodium salt monohydrate 5-Nitroacenaphthene
Type of Toxicity
FR SQE AB AB
LC LC FR FR LC LC LC SQE AB LC
5-Nitro-o-anisidine Delisted December 8, 2006 [Click here for the basis for delisting] cancer - 20 -
SQE AB AB
Date Listed
1-Oct-89 1-Oct-89 1-Oct-89
Chemical
Type of Toxicity
o -Nitroanisole Nitrobenzene Nitrobenzene 4-Nitrobiphenyl 6-Nitrochrysene Nitrofen (technical grade) 2-Nitrofluorene Nitrofurantoin Nitrofurazone 1-[(5-Nitrofurfurylidene)-amino]-2imidazolidinone N-[4-(5-Nitro-2-furyl)-2thiazolyl]acetamide
cancer cancer male cancer cancer cancer cancer male cancer
Listing Mechanism AB
CAS No.
Date Listed
SQE AB SQE AB AB AB
91-23-6 98-95-3 98-95-3 92-93-3 7496-02-8 1836-75-5 607-57-8 67-20-9 59-87-0
1-Oct-92 26-Aug-97 30-Mar-10 1-Apr-88 1-Oct-90 1-Jan-88 1-Oct-90 1-Apr-91 1-Jan-90
cancer
SQE
555-84-0
1-Apr-88
cancer
SQE
531-82-8
1-Apr-88
Nitrogen mustard (Mechlorethamine) Nitrogen mustard (Mechlorethamine) Nitrogen mustard hydrochloride (Mechlorethamine hydrochloride) Nitrogen mustard hydrochloride (Mechlorethamine hydrochloride) Nitrogen mustard N-oxide Nitrogen mustard N-oxide hydrochloride Nitromethane 2-Nitropropane 1-Nitropyrene 4-Nitropyrene N-Nitrosodiethanolamine N-Nitrosodiethylamine N-Nitrosodimethylamine N-Nitrosodi-n -butylamine N-Nitrosodi-n -propylamine p -Nitrosodiphenylamine N-Nitrosodiphenylamine
cancer developmental
SQE SQE
51-75-2 51-75-2
1-Jan-88 1-Jan-89
cancer
SQE
55-86-7
1-Apr-88
developmental cancer
FR SQE
55-86-7 126-85-2
1-Jul-90 1-Apr-88
cancer cancer cancer cancer cancer cancer cancer cancer cancer cancer cancer cancer
SQE SQE AB AB SQE SQE SQE SQE SQE SQE SQE
302-70-5 75-52-5 79-46-9 5522-43-0 57835-92-4 1116-54-7 55-18-5 62-75-9 924-16-3 621-64-7 156-10-5 86-30-6
1-Apr-88 1-May-97 1-Jan-88 1-Oct-90 1-Oct-90 1-Jan-88 1-Oct-87 1-Oct-87 1-Oct-87 1-Jan-88 1-Jan-88 1-Apr-88
3-(N-Nitrosomethylamino) propionitrile 4-(N-Nitrosomethylamino)-1-(3pyridyl)1-butanone N-Nitrosomethylethylamine N-Nitrosomethylvinylamine N-Nitrosomorpholine N-Nitroso-N-ethylurea N-Nitroso-N-methylurea N-Nitroso-N-methylurethane N-Nitrosonornicotine
cancer
AB
60153-49-3
1-Apr-90
cancer cancer cancer cancer cancer cancer cancer cancer
AB LC SQE SQE SQE SQE SQE SQE
64091-91-4 10595-95-6 4549-40-0 59-89-2 759-73-9 684-93-5 615-53-2 16543-55-8
1-Apr-90 1-Oct-89 1-Jan-88 1-Jan-88 1-Oct-87 1-Oct-87 1-Apr-88 1-Jan-88
AB AB
AB
- 21 -
Chemical
Type of Toxicity
Listing Mechanism
N-Nitrosopiperidine N-Nitrosopyrrolidine N-Nitrososarcosine o -Nitrotoluene Nitrous oxide Norethisterone (Norethindrone) Norethisterone (Norethindrone) Norethisterone acetate (Norethindrone acetate) Norethisterone (Norethindrone) /Ethinyl estradiol Norethisterone (Norethindrone) /Mestranol Norethynodrel Norgestrel
cancer cancer cancer cancer developmental cancer developmental
SQE SQE SQE
developmental
FR
developmental
FR
developmental cancer developmental
FR
Ochratoxin A Oil Orange SS Oral contraceptives, combined Oral contraceptives, sequential Oryzalin Oxadiazon Oxadiazon Oxazepam Oxazepam p,p'-Oxybis(benzenesulfonyl hydrazide) Oxydemeton methyl Oxymetholone Oxymetholone Oxytetracycline (internal use) (internal hydrochloride use) Oxythioquinox (Chinomethionat) Oxythioquinox (Chinomethionat)
cancer cancer cancer cancer cancer cancer developmental cancer developmental
AB SQE LC LC
developmental female, male cancer developmental developmental developmental cancer developmental
LC AB
CAS No.
Date Listed
100-75-4 930-55-2 13256-22-9 88-72-2 10024-97-2 68-22-4 68-22-4
1-Jan-88 1-Oct-87 1-Jan-88 15-May-98 1-Aug-08 1-Oct-89 1-Apr-90
51-98-9 68-22-4 57-63-6 68-22-4 72-33-3 68-23-5 6533-00-2
1-Oct-91
1-Apr-90 27-Feb-01 1-Apr-90
303-47-9 2646-17-5 ----19044-88-3 19666-30-9 19666-30-9 604-75-1 604-75-1
1-Jul-90 1-Apr-88 1-Oct-89 1-Oct-89 12-Sep-08 1-Jul-91 15-May-98 1-Oct-94 1-Oct-92
AB AB
80-51-3 301-12-2 434-07-1 434-07-1 79-57-2 2058-46-0 2439-01-2 2439-01-2
7-Aug-09 6-Nov-98 1-Jan-88 1-May-97 1-Jan-91 1-Oct-91 20-Aug-99 6-Nov-98
Paclitaxel
developmental, female, male
FR
33069-62-4
26-Aug-97
Palygorskite fibers (> 5mm in length) Panfuran S Paramethadione Penicillamine Pentachlorophenol Pentobarbital sodium
cancer cancer developmental developmental cancer developmental
AB
SQE FR FR AB FR
12174-11-7 794-93-4 115-67-3 52-67-5 87-86-5 57-33-0
28-Dec-99 1-Jan-88 1-Jul-90 1-Jan-91 1-Jan-90 1-Jul-90
AB LC
LC FR
AB
FR
AB
SQE AB
AB FR
SQE FR
FR FR
- 22 -
1-Apr-90
Chemical Pentostatin Phenacemide Phenacetin Phenazopyridine Phenazopyridine hydrochloride Phenesterin Phenobarbital Phenolphthalein Phenoxybenzamine Phenoxybenzamine hydrochloride Phenprocoumon o -Phenylenediamine and its salts o -Phenylenediamine o -Phenylenediamine dihydochloride Phenyl glycidyl ether Phenyl glycidyl ether Phenylhydrazine and its salts Phenylhydrazine Phenylhydrazine hydrochloride o -Phenylphenate, sodium o -Phenylphenol Phenylphosphine PhiP(2-Amino-1-methyl-6phenylimidazol[4,5-b]pyridine) Pimozide Pipobroman Pirimicarb Plicamycin Polybrominated biphenyls Polybrominated biphenyls Polychlorinated biphenyls Polychlorinated biphenyls Polychlorinated biphenyls (containing 60 or more percent percent chlorine by molecular weight) Polychlorinated dibenzo-p -dioxins Polychlorinated dibenzofurans Polygeenan Ponceau MX Ponceau 3R Potassium bromate Potassium dimethyldithiocarbamate Pravastatin sodium
Type of Toxicity developmental developmental cancer cancer cancer cancer cancer cancer cancer cancer developmental cancer
Listing Mechanism FR FR LC SQE SQE SQE AB AB
SQE SQE FR AB
cancer male cancer
AB
cancer cancer developmental cancer developmental, female developmental cancer developmental cancer developmental cancer developmental
AB
LC
AB
cancer cancer cancer cancer cancer cancer cancer developmental developmental
AB LC
AB FR
FR AB
FR SQE AB LC SQE
SQE FR FR SQE SQE SQE AB AB FR - 23 -
CAS No. 53910-25-1 63-98-9 62-44-2 94-78-0 136-40-3 3546-10-9 50-06-6 77-09-8 59-96-1 63-92-3 435-97-2 95-54-5
Date Listed 1-Sep-96 1-Jul-90 1-Oct-89 1-Jan-88 1-Jan-88 1-Jul-89 1-Jan-90 15-May-98 1-Apr-88 1-Apr-88 1-Oct-92 15-May-98
122-60-1 122-60-1 ---
1-Oct-90 7-Aug-09 1-Jul-92
132-27-4 90-43-7 638-21-1 105650-23-5
1-Jan-90 4-Aug-00 7-Aug-09 1-Oct-94
2062-78-4 54-91-1 23103-98-2 18378-89-7 ---------
20-Aug-99 1-Jul-90 1-Jul-08 1-Apr-90 1-Jan-88 1-Oct-94 1-Oct-89 1-Jan-91
------53973-98-1 3761-53-3 3564-09-8 7758-01-2 128-03-0 81131-70-6
1-Jan-88 1-Oct-92 1-Oct-92 1-Jan-88 1-Apr-88 1-Apr-88 1-Jan-90 30-Mar-99 3-Mar-00
Chemical
Type of Toxicity
Prednisolone sodium phosphate Primidone Procarbazine Procarbazine hydrochloride Procarbazine hydrochloride Procymidone Progesterone Pronamide Propachlor 1,3-Propane sultone Propargite Propargite beta-Propiolactone Propoxur Propylene glycol mono-t -butyl ether Propylene oxide Propylthiouracil Propylthiouracil Pymetrozine Pyridine Pyrimethamine
developmental cancer cancer cancer developmental cancer cancer cancer cancer cancer cancer developmental cancer cancer cancer cancer cancer developmental cancer cancer developmental
Quazepam Quinoline and its strong acid salts Quizalofop-ethyl Radionuclides Reserpine Residual (heavy) fuel oils Resmethrin Resmethrin Retinol/retinyl esters, when in daily dosages in excess of 10,000 IU, or 3,000 retinol equivalents. (NOTE: Retinol/retinyl esters are required and essential for maintenance of normal reproductive function. The recommended daily level during pregnancy is 8,000 IU.) Ribavirin Ribavirin Riddelliine Rifampin
Listing Mechanism
CAS No.
Date Listed
AB AB FR
125-02-0 125-33-7 671-16-9 366-70-1 366-70-1 32809-16-8 57-83-0 23950-58-5 1918-16-7 1120-71-4 2312-35-8 2312-35-8 57-57-8 114-26-1 57018-52-7 75-56-9 51-52-5 51-52-5 123312-89-0 110-86-1 58-14-0
20-Aug-99 20-Aug-99 1-Jan-88 1-Jan-88 1-Jul-90 1-Oct-94 1-Jan-88 1-May-96 27-Feb-01 1-Jan-88 1-Oct-94 15-Jun-99 1-Jan-88 11-Aug-06 11-Jun-04 1-Oct-88 1-Jan-88 1-Jul-90 22-Mar-11 17-May-02 29-Jan-99
developmental cancer male
FR SQE SQE
36735-22-5 --76578-14-8
26-Aug-97 24-Oct-97 24-Dec-99
cancer cancer cancer cancer developmental
SQE LC AB
--50-55-5 --10453-86-8 10453-86-8
1-Jul-89 1-Oct-89 1-Oct-90 1-Jul-08 6-Nov-98
developmental developmental male cancer developmental, female
SQE FR FR LC
--36791-04-5 36791-04-5 23246-96-0
1-Jul-89 1-Apr-90 27-Feb-01 3-Dec-04
FR
13292-46-1
27-Feb-01
FR AB
SQE SQE FR AB SQE AB AB
SQE AB AB
SQE AB AB
SQE SQE FR
AB AB
- 24 -
Listing Mechanism
CAS No.
LC
81-07-2
SQE SQE LC FR LC AB
128-44-9 94-59-7 --309-43-3 7446-34-6 --68308-34-9
SQE
---
AB AB
128-04-1 62-74-8
30-Mar-99 6-Nov-98
LC
---
27-Feb-87
AB FR FR
148477-71-8 52-01-7 10418-03-8 10048-13-2 3810-74-0
8-Oct-10 1-May-97 1-May-97 1-Apr-88 1-Jan-91
18883-66-4 18883-66-4
20-Aug-99 1-Jan-88
SQE SQE
--96-09-3 95-06-7
14-Mar-03 1-Oct-88 1-Jan-88
AB
599-79-1
15-May-98
Sulfasalazine (salicylazosulfapyridine) male Sulfur dioxide developmental developmental, Sulindac female
FR SQE
599-79-1 7446-09-5
29-Jan-99 29-Jul-11
FR
38194-50-2
29-Jan-99
Talc containing asbestiform fibers Tamoxifen and its salts
AB SQE
--10540-29-1
1-Apr-90 1-Sep-96
Chemical
Saccharin Delisted April 6, 2001 [Click here for the basis for delisting]
Type of Toxicity
cancer
Saccharin, sodium Delisted January 17, 2003 [Click here for the basis for delisting] cancer
Safrole Salted fish, Chinese-style Secobarbital sodium Selenium sulfide Sermorelin acetate Shale-oils Silica, crystalline (airborne particles of respirable size)
cancer cancer developmental cancer developmental cancer
FR
cancer
Sodium dimethyldithiocarbamate developmental Sodium fluoroacetate male Soots, tars, and mineral oils (untreated and mildly treated oils and used engine oils) cancer Spirodiclofen Spironolactone Stanozolol Sterigmatocystin Streptomycin sulfate
cancer cancer cancer cancer developmental
SQE
developmental, female, male cancer
Streptozocin (streptozotocin) Streptozotocin (streptozocin) Strong inorganic acid mists containing sulfuric acid cancer Styrene oxide cancer Sulfallate cancer
FR
SQE AB
Sulfasalazine (salicylazosulfapyridine) cancer
cancer cancer - 25 -
Date Listed
1-Oct-89
1-Jan-88 1-Jan-88 29-Apr-11 1-Oct-92 1-Oct-89 20-Aug-99 1-Apr-90 1-Oct-88
Chemical Tamoxifen citrate Temazepam Teniposide Terbacil Terrazole Testosterone and its esters Testosterone cypionate Testosterone enanthate 2,3,7,8-Tetrachlorodibenzo-p -dioxin (TCDD) 2,3,7,8-Tetrachlorodibenzo-p -dioxin (TCDD) 1,1,2,2-Tetrachloroethane Tetrachloroethylene (Perchloroethylene) p-a,a,a- Tetrachlorotoluene Tetracycline (internal use) Tetracyclines (internal use) Tetracycline hydrochloride (internal use) Tetrafluoroethylene Tetranitromethane Thalidomide Thioacetamide 4,4'-Thiodianiline Thiodicarb Thioguanine Thiophanate methyl Thiouracil Thiourea Thorium dioxide Titanium dioxide (airborne, unbound particles of respirable size) Tobacco, oral use of smokeless products Tobacco smoke Tobacco smoke (primary) Tobramycin sulfate Toluene Toluene Toluene diisocyanate o -Toluidine o -Toluidine hydrochloride
Type of Toxicity developmental developmental developmental developmental cancer cancer developmental developmental cancer
Listing Mechanism FR FR FR
CAS No.
Date Listed
AB SQE FR FR
54965-24-1 846-50-4 29767-20-2 5902-51-2 2593-15-9 58-22-0 58-20-8 315-37-7
1-Jul-90 1-Apr-90 1-Sep-96 18-May-99 1-Oct-94 1-Apr-88 1-Oct-91 1-Apr-90
SQE
1746-01-6
1-Jan-88
developmental cancer
AB AB
1746-01-6 79-34-5
1-Apr-91 1-Jul-90
cancer cancer developmental developmental
SQE AB FR FR
127-18-4 5216-25-1 60-54-8 ---
1-Apr-88 1-Jan-90 1-Oct-91 1-Oct-92
developmental cancer cancer developmental cancer cancer cancer developmental female, male cancer cancer cancer
FR
SQE LC
64-75-5 116-14-3 509-14-8 50-35-1 62-55-5 139-65-1 59669-26-0 154-42-7 23564-05-8 141-90-2 62-56-6 1314-20-1
1-Jan-91 1-May-97 1-Jul-90 1-Jul-87 1-Jan-88 1-Apr-88 20-Aug-99 1-Jul-90 18-May-99 11-Jun-04 1-Jan-88 27-Feb-87
LC
---
2-Sep-11
SQE SQE
-----
1-Apr-88 1-Apr-88
SQE FR SQE
--49842-07-1 108-88-3 108-88-3 26471-62-5 95-53-4 636-21-5
1-Apr-88 1-Jul-90 1-Jan-91 7-Aug-09 1-Oct-89 1-Jan-88 1-Jan-88
AB
AB
AB SQE SQE SQE AB
FR AB AB
cancer cancer cancer developmental, female, male developmental developmental female cancer cancer cancer - 26 -
LC
LC SQE SQE
Chemical
para-Toluidine Delisted October 29, 1999 [Click here for the basis for delisting]
Toxaphene (Polychlorinated camphenes) Toxins derived from Fusarium moniliforme (Fusarium verticillioides) Treosulfan
Listing Mechanism
CAS No.
cancer
AB
106-49-0
1-Jan-90
cancer
SQE
8001-35-2
1-Jan-88
LC
--299-75-2
7-Aug-09 27-Feb-87 30-Mar-99 1-Apr-90
Type of Toxicity
Date Listed
cancer cancer developmental, female, male developmental
FR
43121-43-3 28911-01-5
cancer
AB
78-48-8
25-Feb-11
Tributyltin methacrylate Trichlormethine (Trimustine hydrochloride)
developmental
AB
2155-70-6
1-Dec-99
cancer
AB
817-09-4
1-Jan-92
Trichloroethylene 2,4,6-Trichlorophenol 1,2,3-Trichloropropane Trientine hydrochloride Triforine 1,3,5-Triglycidyl-s-triazinetrione Trilostane Trimethadione 2,4,5-Trimethylaniline and its strong acid salts Trimethyl phosphate Trimetrexate glucuronate 2,4.6-Trinitrotoluene (TNT) Triphenyltin hydroxide Triphenyltin hydroxide
cancer cancer cancer developmental developmental male developmental developmental
SQE SQE AB
79-01-6 88-06-2 96-18-4 38260-01-4 26644-46-2 2451-62-9 13647-35-3 127-48-0
1-Apr-88 1-Jan-88 1-Oct-92 27-Feb-01 18-Jun-99 7-Aug-09 1-Apr-90 1-Jan-91
cancer cancer developmental cancer cancer developmental
SQE
AB
--512-56-1 82952-64-5 118-96-7 76-87-9 76-87-9
24-Oct-97 1-May-96 26-Aug-97 19-Dec-08 1-Jul-92 18-Mar-02
cancer
LC
68-76-8
1-Oct-89
cancer cancer cancer
SQE AB SQE
52-24-4 115-96-8 126-72-7
1-Jan-88 1-Apr-92 1-Jan-88
cancer cancer cancer
SQE
SQE SQE
13674-87-8 62450-06-0 62450-07-1
28-Oct-11 1-Apr-88 1-Apr-88
Triadimefon Triazolam S,S,S-Tributyl phosphorotrithioate (Tribufos, DEF)
Tris(aziridinyl)-p-benzoquinone (Triaziquone) Delisted December 8, 2006 [Click here for the basis for delisting]
Tris(1-aziridinyl)phosphine sulfide (Thiotepa) Tris(2-chloroethyl) phosphate Tris(2,3-dibromopropyl)phosphate Tris(1,3-dichloro-2-propyl) phosphate (TDP) Trp-P-1 (Tryptophan-P-1) Trp-P-2 (Tryptophan-P-2)
LC AB
FR AB LC
FR FR
AB FR SQE
AB
- 27 -
Chemical
Type of Toxicity
Listing Mechanism
CAS No.
LC
72-57-1
1-Oct-89
Date Listed
Trypan blue (commercial grade)
cancer
Unleaded gasoline (wholly vaporized) Uracil mustard
cancer cancer developmental, female, male cancer developmental developmental
SQE SQE
--66-75-1
1-Apr-88 1-Apr-88
FR SQE AB FR
66-75-1 51-79-6 51-79-6 97048-13-0
1-Jan-92 1-Jan-88 1-Oct-94 1-Apr-90
developmental
SQE
99-66-1
1-Jul-87
cancer developmental cancer developmental developmental cancer cancer cancer female, male
AB
LC
1314-62-1 143-67-9 50471-44-8 50471-44-8 2068-78-2 593-60-2 75-01-4 100-40-3 100-40--3
cancer
AB
106-87-6
1-Jul-90
female, male cancer
LC AB
106-87-6 75-02-5
1-Aug-08 1-May-97
AB
79-00-5
1-Oct-90
SQE LC
81-81-2 ---
1-Jul-87 18-Dec-09 1-Jan-91
Uracil mustard Urethane (Ethyl carbamate) Urethane (Ethyl carbamate) Urofollitropin Valproate (Valproic acid) Vanadium pentoxide (orthorhombic crystalline form) Vinblastine sulfate Vinclozolin Vinclozolin Vincristine sulfate Vinyl bromide Vinyl chloride 4-Vinylcyclohexene 4-Vinylcyclohexene 4-Vinyl-1-cyclohexene diepoxide (Vinyl cyclohexenedioxide) Vinyl cyclohexene dioxide (4-Vinyl-1cyclohexene diepoxide) Vinyl fluoride
FR AB AB
FR SQE LC AB
Vinyl trichloride (1,1,2-Trichloroethane) cancer
11-Feb-05 1-Jul-90 20-Aug-99 15-May-98 1-Jul-90 1-Oct-88 27-Feb-87 1-May-96 7-Aug-09
Warfarin Wood dust
developmental cancer
2,6-Xylidine (2,6-Dimethylaniline)
cancer
AB
87-62-7
Zalcitabine Zidovudine (AZT)
LC LC
7481-89-2 30516-87-1
7-Aug-09 18-Dec-09
Zileuton
cancer cancer cancer, developmental, female
FR
111406-87-2
22-Dec-00
Zineb Delisted October 29, 1999 [Click here for the basis for delisting]
cancer
AB
12122-67-7
1-Jan-90
- 28 -
Chemical
Type of Toxicity
Listing Mechanism
CAS No.
Date Listed
a
Where a source or product results in exposures by multiple routes, the total exposure must be considered. For example, the MADL for benzene is exceeded when the absorbed dose exceeds 24 µg/day. If only inhalation and oral exposure occurs, the benzene MADL is exceeded when: (oral dose ÷ 24 µg/day) + (inhalation dose ÷ 49 µg/day) > 1.0. b
Level represents absorbed dose (rounded from 6,525 µg/day ). Since 100% of ingested toluene is absorbed, oral dose is equivalent to istered dose. It is assumed that roughly 50% of the dose istered by the inhalation route is absorbed. Therefore the MADL for inhaled toluene is 13,000 µg/day (rounded from 13,050 µg/day ), corresponding to an absorbed dose of 6,525 µg/day.
- 29 -
CITY
vise and republish ive toxicity. For ndpoints shown in been removed. A
s Qualified Code. For those nk to the hemical Abstracts esented as a e chemicals for MADL) for or those NSRLs or to the
NSRL or MADL a (µg/day)
2 90 (inhalation) 10
0.2
0.2 140
0.7 0.00008
- 30 -
NSRL or MADL (µg/day)a 3
0.04
20 0.2 0.03
9
5 0.04
0.7
- 31 -
NSRL or MADL (µg/day)a 100 5 7
20
0.06 (inhalation) 10 (except inhalation) 100 fibers/day (inhalation)
0.8 4.4 0.06 0.4
6
0.033 (oral) 6.4 (oral) 13 (inhalation) - 32 -
NSRL or MADL (µg/day)a 24 (oral) 49 (inhalation)
0.001
0.096 (oral) 0.11 (oral) 1.1
0.06
4 30
0.1 0.1 0.0002
0.3
0.02
5 64
- 33 -
NSRL or MADL (µg/day)a
0.4
4000
0.7
4.1 (oral)
0.05 (inhalation) 5 300
4.1
5
0.7
- 34 -
NSRL or MADL (µg/day)a
0.002
0.5 0.04
8
8 0.37 0.48
150
20 (oral) 40 (inhalation)
0.3 5 40
200 3
- 35 -
NSRL or MADL (µg/day)a
3.3
0.003
0.001 (inhalation) 8.2 (oral) 0.35 (oral) 3 50
200
0.3
- 36 -
NSRL or MADL (µg/day)a
5 3
1
1
100 0.01 40
9
910 - 37 -
NSRL or MADL (µg/day)a 2 (DDT, DDE, DDD in combination) 2 (DDT, DDE, DDD in combination) 2 (DDT, DDE, DDD in combination)
2
30 50 5 0.2
0.2 0.0030 (oral) 0.0054 (oral) 0.0050 (oral)
0.1 - 38 -
NSRL or MADL (µg/day)a 3.1 (oral) 4.3 (inhalation)
20 0.6
100
50 200 (inhalation)
9.7
0.04
310 For intravenous exposure: 4200 (adults) 600 (infant boys, age 29 days- 24 mos.) 210 (neonatal infant boys, age 0-28 days).
- 39 -
NSRL or MADL (µg/day)a For oral exposure: 410 (adults) 58 (infant boys, age 29 days24 mos.) 20 (neonatal infant boys, age 0-28 days). 0.002
0.4 20
2200
0.15 0.19
0.2
2 0.003 0.044 0.059
- 40 -
NSRL or MADL (µg/day)a 0.05 0.001 20 8.7 2200 (oral) 38
2
30
0.09 0.09 0.1 56 (oral) 170 (oral) as 32% pesticidal formulation 200
- 41 -
NSRL or MADL (µg/day)a
9
0.02
54 (inhalation) 41 (oral) 700 (oral and inhalation) 6700 (dermal) 7
0.2 (oral) 3 (inhalation)
10 750 (oral) 960 (inhalation)
- 42 -
NSRL or MADL (µg/day)a 1100 (oral) 1400 (inhalation) 63 (oral) 98 (oral) 0.01
2 20
20
200 40 0.3
- 43 -
NSRL or MADL (µg/day)a 20
0.1 0.5 0.54
0.07
10
0.2 0.08
0.4
- 44 -
NSRL or MADL (µg/day)a 0.2 0.3 0.5 0.6 0.0002 20
120 (oral)
0.04 0.2 0.8
0.5
7.4
- 45 -
NSRL or MADL (µg/day)a
0.09
0.5 15 (oral) 23 (oral) 58 (oral) 41 (oral)
460
0.6
0.46 0.41 0.005
- 46 -
NSRL or MADL (µg/day)a
0.028
810 (inhalation) 160
0.03 0.0084 (oral) 0.5
20 0.8 0.4 0.6
0.058 (oral) 0.090 (inhalation) 0.18 29
- 47 -
NSRL or MADL (µg/day)a
7
0.2 0.08 3200 (inhalation) 17000 (dermal)
2
0.8
0.04 0.00009
0.07
- 48 -
NSRL or MADL (µg/day)a
0.18
0.11
28 5.8 0.4
0.8 0.4
100 70 6
10 - 49 -
NSRL or MADL (µg/day)a
9
0.5 0.4 0.5
39
0.3 0.02 0.04 0.06 0.1 30
80
0.014
0.03 0.1
0.03 0.006 0.006 0.5 - 50 -
NSRL or MADL (µg/day)a 0.07
0.3
40
- 51 -
NSRL or MADL (µg/day)a
300 4 5 0.005 2 0.2 0.3
26 44 5
1 1.4 200
0.02 0.09
1200 200 40 1 720
- 52 -
NSRL or MADL (µg/day)a
0.05 0.06
0.3
0.05
0.7
590
0.06
- 53 -
NSRL or MADL (µg/day)a
3
23 (oral) 58 (oral) as a 40% pesticidal formulation
0.02
0.006
4 4
- 54 -
NSRL or MADL (µg/day)a
0.000005
3
14
0.059 0.1 0.05
600 (oral) 10
7000b 20 4 5 - 55 -
NSRL or MADL (µg/day)a
0.6
50 (oral) 80 (inhalation) 10
24 8.2
0.06 0.3
0.03 0.2 - 56 -
NSRL or MADL (µg/day)a
0.7
3
10
110
- 57 -
NSRL or MADL (µg/day)a
st be considered. day. If only 4 µg/day) +
oluene is the dose s 13,000 µg/day
- 58 -
Chemical
A-alpha-C (2-Amino-9H-pyrido[2,3b]indole) Acetaldehyde Acetamide Acetazolamide Acetochlor Acetohydroxamic acid 2-Acetylaminofluorene Acifluorfen sodium Acrylamide Acrylamide Acrylonitrile Actinomycin D Actinomycin D
Type of Toxicity
cancer cancer cancer developmental cancer developmental cancer cancer cancer developmental, male cancer cancer developmental -1-
Listing Mechanism
AB SQE AB FR
SQE FR SQE AB AB AB
FR LC FR
CAS No.
Date Listed
26148-68-5 75-07-0 60-35-5 59-66-5 34256-82-1 546-88-3 53-96-3 62476-59-9 79-06-1
1-Jan-90 1-Apr-88 1-Jan-90 20-Aug-99 1-Jan-89 1-Apr-90 1-Jul-87 1-Jan-90 1-Jan-90
79-06-1 107-13-1 50-76-0 50-76-0
25-Feb-11 1-Jul-87 1-Oct-89 1-Oct-92
Listing Mechanism
CAS No.
cancer cancer cancer
SQE SQE SQE
3688-53-7 --15972-60-8
1-Jul-87 1-Jan-88 1-Jan-89
cancer cancer developmental
SQE SQE SQE
--309-00-2 302-79-4
1-Jul-88 1-Jul-88 1-Jan-89
AB FR
107-05-1 28981-97-7
1-Jan-90 1-Jul-90
Altretamine Amantadine hydrochloride Amikacin sulfate 2-Aminoanthraquinone p -Aminoazobenzene o -Aminoazotoluene
cancer developmental developmental, male developmental developmental cancer cancer cancer
FR FR
FR LC AB SQE
645-05-6 665-66-7 39831-55-5 117-79-3 60-09-3 97-56-3
20-Aug-99 27-Feb-01 1-Jul-90 1-Oct-89 1-Jan-90 1-Jul-87
4-Aminobiphenyl (4-aminodiphenyl)
cancer
LC
92-67-1
27-Feb-87
1-Amino-2,4-dibromoanthraquinone 3-Amino-9-ethylcarbazole hydrochloride 2-Aminofluorene Aminoglutethimide Aminoglycosides 1-Amino-2-methylanthraquinone 2-Amino-5-(5-nitro-2-furyl)-1,3,4thiadiazole 4-Amino-2-nitrophenol
cancer
AB
81-49-2
26-Aug-97
cancer cancer developmental developmental cancer
SQE
6109-97-3 153-78-6 125-84-8 --82-28-0
1-Jul-89 29-Jan-99 1-Jul-90 1-Oct-92 1-Oct-89
cancer cancer developmental, female developmental, female, male developmental cancer developmental cancer developmental female, male
SQE SQE
712-68-5 119-34-6
1-Jul-87 29-Jan-99
SQE
54-62-6
1-Jul-87
FR AB
19774-82-4 33089-61-1 61-82-5 14028-44-5 51264-14-3 994-05-8 ---
26-Aug-97 30-Mar-99 1-Jul-87 15-May-98 7-Aug-09 18-Dec-09 1-Apr-90
AB
--63-05-8
27-Feb-87 3-May-11
FR
---
Chemical AF-2;[2-(2-furyl)-3-(5-nitro-2furyl)]acrylamide Aflatoxins Alachlor Alcoholic beverages, when associated with alcohol abuse Aldrin All-trans retinoic acid Allyl chloride Delisted October 29, 1999 [Click here for the basis for delisting]
Alprazolam
Aminopterin
Type of Toxicity
SQE
FR FR LC
Amiodarone hydrochloride Amitraz Amitrole Amoxapine Amsacrine tert-Amyl methyl ether Anabolic steroids Analgesic mixtures containing Phenacetin cancer Androstenedione cancer Angiotensin converting enzyme (ACE) inhibitors developmental
SQE FR LC LC
FR LC
-2-
Date Listed
1-Oct-92
Chemical Aniline Aniline hydrochloride o -Anisidine o -Anisidine hydrochloride Anisindione Anthraquinone Antimony oxide (Antimony trioxide) Aramite Areca nut Aristolochic acids
Type of Toxicity cancer cancer cancer cancer developmental cancer cancer cancer cancer cancer
AB
SQE
----
27-Feb-87 1-May-97
LC
1332-21-4
27-Feb-87
SQE
50-78-2 29122-68-7 492-80-8 34031-32-8 71751-41-2 320-67-2 115-02-6 446-86-6 446-86-6 103-33-3
1-Jul-90 26-Aug-97 1-Jul-87 29-Jan-99 3-Dec-10 1-Jan-92 1-Jul-87 27-Feb-87 1-Sep-96 1-Jan-90
--5534-09-8
1-Oct-92 15-May-98
AB
AB SQE LC LC
LC
cancer
Aspirin (NOTE: It is especially important not to use aspirin during the last three months of pregnancy, unless specifically directed to do so by a physician because it may cause problems in the unborn child or complications during delivery.) Atenolol Auramine Auranofin Avermectin B1 (Abamectin) Azacitidine Azaserine Azathioprine Azathioprine Azobenzene
developmental, female developmental cancer developmental developmental cancer cancer cancer developmental cancer
Benomyl Benthiavalicarb-isopropyl Benz[a]anthracene
developmental developmental developmental, male cancer cancer
Benzene
cancer -3-
Date Listed 1-Jan-90 15-May-98 1-Jul-87 1-Jul-87 1-Oct-92 28-Sep-07 1-Oct-90 1-Jul-87 3-Feb-06 9-Jul-04
SQE SQE FR
Asbestos
CAS No. 62-53-3 142-04-1 90-04-0 134-29-2 117-37-3 84-65-1 1309-64-4 140-57-8 -----
AB
Arsenic (inorganic arsenic compounds) cancer Arsenic (inorganic oxides) developmental
Barbiturates Beclomethasone dipropionate
Listing Mechanism
FR
SQE FR AB
AB SQE LC FR AB FR FR
SQE SQE
17804-35-2 177406-68-7 56-55-3
LC
71-43-2
AB
1-Jul-91 1-Jul-08 1-Jul-87 27-Feb-87
Chemical
Type of Toxicity
Listing Mechanism
CAS No.
Date Listed
developmental, male cancer cancer developmental cancer cancer cancer cancer cancer cancer developmental cancer cancer
LC FR FR SQE SQE SQE AB SQE SQE FR AB SQE
71-43-2 92-87-5 ----205-99-2 205-82-3 207-08-9 271-89-6 50-32-8 98-07-7 5411-22-3 100-44-7 1694-09-3
Beryllium and beryllium compounds Beryllium Beryllium oxide Beryllium sulfate Betel quid with tobacco Betel quid without tobacco
cancer
SQE
---
1-Oct-87
cancer cancer
AB LC
-----
1-Jan-90 3-Feb-06
2,2-Bis(bromomethyl)-1,3-propanediol Bis(2-chloroethyl)ether N,N-Bis(2-chloroethyl)-2naphthylamine (Chlornapazine) Bischloroethyl nitrosourea (BCNU) (Carmustine) Bischloroethyl nitrosourea (BCNU) (Carmustine) Bis(chloromethyl)ether Bis(2-chloro-1-methylethyl)ether, technical grade Bitumens, extracts of steam-refined and air refined Bracken fern Bromacil lithium salt Bromacil lithium salt Bromate Bromochloroacetic acid Bromodichloromethane Bromoethane Bromoform
cancer cancer
AB SQE
3296-90-0 111-44-4
1-May-96 1-Apr-88
cancer
LC
494-03-1
27-Feb-87
cancer
SQE
154-93-8
1-Jul-87
FR LC
154-93-8 542-88-1
1-Jul-90 27-Feb-87
SQE
---
29-Oct-99
AB AB
AB
----53404-19-6 53404-19-6 15541-45-4 5589-96-8 75-27-4 74-96-4 75-25-2
1-Jan-90 1-Jan-90 18-May-99 17-Jan-03 31-May-02 6-Apr-10 1-Jan-90 22-Dec-00 1-Apr-91
AB
106-94-5
Benzene Benzidine [and its salts] Benzidine-based dyes Benzodiazepines Benzo[b]fluoranthene Benzo[j]fluoranthene Benzo[k]fluoranthene Benzofuran Benzo[a]pyrene Benzotrichloride Benzphetamine hydrochloride Benzyl chloride Benzyl violet 4B
1-Bromopropane (1-BP)
developmental cancer cancer cancer cancer developmental male cancer cancer cancer cancer cancer developmental, female, male -4-
SQE
AB SQE AB AB
AB AB
26-Dec-97 27-Feb-87 1-Oct-92 1-Oct-92 1-Jul-87 1-Jul-87 1-Jul-87 1-Oct-90 1-Jul-87 1-Jul-87 1-Apr-90 1-Jan-90 1-Jul-87
7-Dec-04
Chemical 2-Bromopropane (2-BP) Bromoxynil Bromoxynil octanoate Butabarbital sodium 1,3-Butadiene
Type of Toxicity
CAS No.
Date Listed
FR SQE
75-26-3 1689-84-5 1689-99-2 143-81-7 106-99-0
31-May-05 1-Oct-90 18-May-99 1-Oct-92 1-Apr-88
developmental, female, male
AB
106-99-0
16-Apr-04
cancer
LC
55-98-1
27-Feb-87
developmental cancer developmental male cancer
SQE AB
SQE
55-98-1 25013-16-5 85-68-7 2426-08-6 3068-88-0
1-Jan-89 1-Jan-90 2-Dec-05 7-Aug-09 1-Jul-87
AB
75-60-5
1-May-96
Cium
cancer developmental, male
SQE
---
1-May-97
Cium and cium compounds
cancer
SQE
---
1-Oct-87
cancer cancer cancer developmental cancer developmental, male cancer
AB SQE AB
331-39-5 2425-06-1 133-06-2 298-46-4 63-25-2
1-Oct-94 1-Oct-88 1-Jan-90 29-Jan-99 5-Feb-10
AB
63-25-2 86-74-8
7-Aug-09 1-May-96
cancer developmental, female, male developmental cancer cancer developmental cancer cancer
AB
1333-86-4
21-Feb-03
SQE SQE SQE AB FR SQE AB
75-15-0 630-08-0 56-23-5 --41575-94-4 60391-92-6 120-80-9
1-Jul-89 1-Jul-89 1-Oct-87 1-Jan-90 1-Jul-90 25-Jan-02 15-Jul-03
AB
---
1,3-Butadiene 1,4-Butanediol dimethanesulfonate (Busulfan) 1,4-Butanediol dimethanesulfonate (Busulfan) Butylated hydroxyanisole Butyl benzyl phthalate (BBP) n-Butyl glycidyl ether beta-Butyrolactone Cacodylic acid
Cium Caffeic acid Captafol Captan Carbamazepine Carbaryl Carbaryl Carbazole Carbon black (airborne, unbound particles of respirable size) Carbon disulfide Carbon monoxide Carbon tetrachloride Carbon-black extracts Carboplatin N-Carboxymethyl-N-nitrosourea Catechol Ceramic fibers (airborne particles of respirable size)
female, male developmental developmental developmental cancer
Listing Mechanism AB
FR AB
AB LC
cancer -5-
FR AB LC
1-Jul-90
Chemical Certain combined chemotherapy for lymphomas Chenodiol Chlorambucil Chlorambucil Chloramphenicol Chlorcyclizine hydrochloride Chlordane Chlordecone (Kepone) Chlordecone (Kepone) Chlordiazepoxide Chlordiazepoxide hydrochloride Chlordimeform Chlorendic acid Chlorinated paraffins (Average chain length, C12;approximately 60 percent chlorine by weight) p -Chloroaniline p -Chloroaniline hydrochloride Chlorodibromomethane Delisted October 29, 1999 [Click here for the basis for delisting]
Chloroethane (Ethyl chloride) 1-(2-Chloroethyl)-3-cyclohexyl-1nitrosourea (CCNU) (Lomustine) 1-(2-Chloroethyl)-3-cyclohexyl-1nitrosourea (CCNU) (Lomustine) 1-(2-Chloroethyl)-3-(4methylcyclohexyl)-1-nitrosourea (Methyl-CCNU)
Chloroform Chloroform Chloromethyl methyl ether (technical grade) 3-Chloro-2-methylpropene 1-Chloro-4-nitrobenzene 4-Chloro-o -phenylenediamine Chloroprene 2-Chloropropionic acid Chlorothalonil p -Chloro-o -toluidine
Listing Mechanism
CAS No.
cancer developmental cancer developmental cancer developmental cancer cancer developmental developmental developmental cancer cancer
LC FR LC SQE LC FR SQE SQE SQE FR FR SQE SQE
--474-25-9 305-03-3 305-03-3 56-75-7 1620-21-9 57-74-9 143-50-0 143-50-0 58-25-3 438-41-5 6164-98-3 115-28-6
27-Feb-87 1-Apr-90 27-Feb-87 1-Jan-89 1-Oct-89 1-Jul-87 1-Jul-88 1-Jan-88 1-Jan-89 1-Jan-92 1-Jan-92 1-Jan-89 1-Jul-89
cancer cancer cancer
SQE AB AB
108171-26-2 106-47-8 20265-96-7
1-Jul-89 1-Oct-94 15-May-98
cancer cancer
AB AB
124-48-1 75-00-3
1-Jan-90 1-Jul-90
cancer
SQE
13010-47-4
1-Jan-88
FR
13010-47-4
1-Jul-90
cancer
SQE
13909-09-6
1-Oct-88
cancer developmental
SQE
67-66-3 67-66-3
1-Oct-87 7-Aug-09
cancer cancer cancer cancer cancer male cancer cancer
LC SQE
107-30-2 563-47-3 100-00-5 95-83-0 126-99-8 598-78-7 1897-45-6 95-69-2
27-Feb-87 1-Jul-89 29-Oct-99 1-Jan-88 2-Jun-00 7-Aug-09 1-Jan-89 1-Jan-90
Type of Toxicity
developmental
LC
SQE
SQE AB LC
SQE AB
-6-
Date Listed
Chemical
Type of Toxicity
p- Chloro-o -toluidine, strong acid salts of cancer p- Chloro-o -toluidine, hydrochloride 5-Chloro-o -toluidine and its strong acid salts Chlorotrianisene Chlorozotocin
cancer cancer cancer
Chlorsulfuron [Click here for the basis for removal of male reproductive toxicity endpoint]
developmental, female, male
Chromium (hexavalent compounds) Chromium (hexavalent compounds) Chrysene C.I. Acid Red 114 C.I. Basic Red 9 monohydrochloride C.I. Direct Blue 15 C.I. Direct Blue 218 C.I. Solvent Yellow 14 Ciclosporin (Cyclosporin A; Cyclosporine)
Cidofovir Cinnamyl anthranilate Cisplatin Citrus Red No. 2 Cladribine Clarithromycin Clobetasol propionate Clofibrate Clomiphene citrate Clorazepate dipotassium Cobalt metal powder Cobalt [II] oxide Cobalt sulfate Cobalt sulfate heptahydrate Cocaine Codeine phosphate Coke oven emissions
cancer developmental, female, male cancer cancer cancer cancer cancer cancer cancer cancer, developmental, female, male cancer cancer cancer developmental developmental developmental, female cancer developmental developmental cancer cancer cancer cancer developmental, female developmental cancer
-7-
Listing Mechanism
CAS No.
AB
---
15-May-98
SQE
FR AB
--569-57-3 54749-90-5
24-Oct-97 1-Sep-96 1-Jan-92
AB
64902-72-3
14-May-99
LC
---
27-Feb-87
SQE
--218-01-9 6459-94-5 569-61-9 2429-74-5 28407-37-6 842-07-9 59865-13-3; 79217-60-0
19-Dec-08 1-Jan-90 1-Jul-92 1-Jul-89 26-Aug-97 26-Aug-97 15-May-98
113852-37-2 87-29-6 15663-27-1 6358-53-8 4291-63-8 81103-11-9
29-Jan-99 1-Jul-89 1-Oct-88 1-Oct-89 1-Sep-96 1-May-97
25122-46-7 637-07-0 50-41-9 57109-90-7 7440-48-4 1307-96-6 10124-43-3 10026-24-1 50-36-2 52-28-8 ---
15-May-98 1-Sep-96 1-Apr-90 1-Oct-92 1-Jul-92 1-Jul-92 20-May-05 2-Jun-00 1-Jul-89 15-May-98 27-Feb-87
AB AB SQE AB AB AB
AB
FR
SQE SQE LC FR FR FR
FR FR FR AB AB LC AB
SQE FR
LC
Date Listed
1-Jan-92
Chemical
Colchicine Conjugated estrogens Conjugated estrogens Creosotes p -Cresidine Cumene Cupferron Cyanazine Cycasin Cycloate Cyclohexanol Delisted January 25, 2002 [Click here for the basis for delisting]
Type of Toxicity developmental, male cancer developmental cancer cancer cancer cancer developmental cancer developmental
Cycloheximide Cyclopenta[cd ]pyrene Cyclophosphamide (anhydrous)
male developmental cancer cancer
Cyclophosphamide (anhydrous) Cyclophosphamide (hydrated)
developmental, female, male cancer
Cyclophosphamide (hydrated) Cyhexatin Cytarabine Cytembena
developmental, female, male developmental developmental cancer
D&C Orange No. 17 D&C Red No. 8 D&C Red No. 9 D&C Red No. 19 Dacarbazine Dacarbazine Daminozide Danazol Dantron (Chrysazin; 1,8Dihydroxyanthraquinone) Daunomycin Daunorubicin hydrochloride 2,4-D butyric acid [Click here for the basis for the removal of developmental toxicity endpoint]
Listing Mechanism
FR LC FR SQE SQE AB
SQE FR SQE AB AB
FR LC
LC SQE developmental FR - female, male LC SQE developmental FR - female, male FR SQE AB
CAS No.
Date Listed
64-86-8 ------120-71-8 98-82-8 135-20-6 21725-46-2 14901-08-7 1134-23-2
1-Oct-92 27-Feb-87 1-Apr-90 1-Oct-88 1-Jan-88 6-Apr-10 1-Jan-88 1-Apr-90 1-Jan-88 19-Mar-99
108-93-0 66-81-9 27208-37-3 50-18-0
6-Nov-98 1-Jan-89 29-Apr-11 27-Feb-87
50-18-0 6055-19-2
1-Jan-89 27-Feb-87
6055-19-2 13121-70-5 147-94-4 21739-91-3
1-Jan-89 1-Jan-89 1-Jan-89 15-May-98 1-Jul-90 1-Oct-90 1-Jul-90 1-Jul-90 1-Jan-88 29-Jan-99 1-Jan-90 1-Apr-90
cancer cancer cancer cancer cancer developmental cancer developmental
AB AB AB AB SQE AB FR
3468-63-1 2092-56-0 5160-02-1 81-88-9 4342-03-4 4342-03-4 1596-84-5 17230-88-5
cancer cancer developmental
AB SQE FR
117-10-2 20830-81-3 23541-50-6
1-Jan-92 1-Jan-88 1-Jul-90
developmental, male
AB
94-82-6
18-Jun-99
FR
-8-
Chemical
Type of Toxicity
Listing Mechanism
CAS No.
Date Listed
DDD (Dichlorodiphenyldichloroethane)
cancer
SQE
72-54-8
1-Jan-89
DDE (Dichlorodiphenyldichloroethylene)
cancer
SQE
72-55-9
1-Jan-89
SQE
50-29-3
1-Oct-87
o,p'-DDT
cancer developmental, female, male
AB
789-02-6
15-May-98
p,p'-DDT DDVP (Dichlorvos)
developmental, female, male cancer
AB
SQE
50-29-3 62-73-7
15-May-98 1-Jan-89
AB
120-36-5
27-Apr-99
developmental cancer cancer cancer
FR LC FR SQE
64-73-3 613-35-4 615-05-4 39156-41-7
1-Jan-92 1-Oct-89 1-Oct-90 1-Jan-88
cancer cancer cancer developmental cancer developmental cancer cancer cancer cancer cancer cancer cancer cancer cancer cancer
SQE SQE AB FR
AB AB
101-80-4 95-80-7 --439-14-5 136-35-6 364-98-7 226-36-8 224-42-0 53-70-3 194-59-2 192-65-4 189-64-0 189-55-9 191-30-0 631-64-1 3252-43-5
1-Jan-88 1-Jan-88 1-Jan-90 1-Jan-92 20-May-05 27-Feb-01 1-Jan-88 1-Jan-88 1-Jan-88 1-Jan-88 1-Jan-88 1-Jan-88 1-Jan-88 1-Jan-88 17-Jun-08 3-May-11
FR
96-12-8
DDT (Dichlorodiphenyltrichloroethane)
2,4-DP (dichloroprop) Delisted January 25, 2002 [Click here for the basis for delisting] developmental
Demeclocycline hydrochloride (internal use) N,N'-Diacetylbenzidine 2,4-Diaminoanisole 2,4-Diaminoanisole sulfate 4,4'-Diaminodiphenyl ether (4,4'Oxydianiline) 2,4-Diaminotoluene Diaminotoluene (mixed) Diazepam Diazoaminobenzene Diazoxide Dibenz[a,h]acridine Dibenz[a,j]acridine Dibenz[a,h]anthracene 7H-Dibenzo[c,g]carbazole Dibenzo[a,e]pyrene Dibenzo[a,h]pyrene Dibenzo[a,i]pyrene Dibenzo[a,l]pyrene Dibromoacetic acid Dibromoacetonitrile
LC FR
SQE SQE SQE SQE SQE SQE SQE SQE
1,2-Dibromo-3-chloropropane (DB) cancer -9-
1-Jul-87
Chemical
Type of Toxicity
1,2-Dibromo-3-chloropropane (DB) male 2,3-Dibromo-1-propanol cancer Dichloroacetic acid cancer Dichloroacetic acid male p -Dichlorobenzene cancer 3,3'-Dichlorobenzidine cancer
Listing Mechanism
LC AB AB
CAS No.
Date Listed
SQE SQE
96-12-8 96-13-9 79-43-6 79-43-6 106-46-7 91-94-1
27-Feb-87 1-Oct-94 1-May-96 7-Aug-09 1-Jan-89 1-Oct-87
AB
612-83-9
15-May-98
AB
AB
72-55-9 764-41-0
30-Mar-10 1-Jan-90
LC
3,3'-Dichlorobenzidine dihydrochloride 1,1-Dichloro-2,2-bis(p chloropheny)ethylene (DDE) 1,4-Dichloro-2-butene 3,3'-Dichloro-4,4'-diamino-diphenyl ether 1,1-Dichloroethane
cancer developmental, male cancer cancer cancer
SQE AB
28434-86-8 75-34-3
1-Jan-88 1-Jan-90
Dichloromethane (Methylene chloride) Dichlorophene Dichlorphenamide Diclofop-methyl Diclofop methyl 1,2-Dichloropropane 1,3-Dichloro-2-propanol (1,3-D) 1,3-Dichloropropene Dicumarol Dieldrin Dienestrol Diepoxybutane Diesel engine exhaust Di(2-ethylhexyl)phthalate
cancer developmental developmental cancer developmental cancer cancer cancer developmental cancer cancer cancer cancer cancer
SQE
SQE FR SQE LC SQE AB SQE
75-09-2 97-23-4 120-97-8 51338-27-3 51338-27-3 78-87-5 96-23-1 542-75-6 66-76-2 60-57-1 84-17-3 1464-53-5 --117-81-7
1-Apr-88 27-Apr-99 27-Feb-01 6-Apr-10 5-Mar-99 1-Jan-90 8-Oct-10 1-Jan-89 1-Oct-92 1-Jul-88 1-Jan-90 1-Jan-88 1-Oct-90 1-Jan-88
Di(2-ethylhexyl)phthalate
developmental, male
AB
117-81-7
24-Oct-03
AB FR AB AB
AB SQE
- 10 -
Listing Mechanism
CAS No.
cancer cancer developmental cancer developmental, female male cancer developmental cancer cancer
SQE LC FR SQE
1615-80-1 56-53-1 56-53-1 64-67-5
1-Jan-88 27-Feb-87 1-Jul-87 1-Jan-88
FR LC
29-Jan-99 7-Aug-09 1-Jul-89 1-May-97 1-Jan-88 1-Apr-93
developmental developmental
AB FR
22494-42-4 2238-07-5 101-90-6 6190-39-2 94-58-6 2973-10-6 68515-49-1/ 26761-40-0 33286-22-5
cancer
SQE
119-90-4
1-Jan-88
cancer
AB
20325-40-0
1-Oct-90
cancer developmental cancer
AB LC
SQE
--127-19-5 60-11-7
cancer cancer
SQE AB
55738-54-0 57-97-6
1-Jan-88 1-Jan-90
3,3'-Dimethylbenzidine (ortho-Tolidine) cancer
SQE
119-93-7
1-Jan-88
3,3'-Dimethylbenzidine dihydrochloride cancer
AB
612-82-8
1-Apr-92
3,3'-Dimethylbenzidine-based dyes metabolized to 3,3'-dimethylbenzidine cancer
AB
---
Chemical
1,2-Diethylhydrazine Diethylstilbestrol (DES) Diethylstilbestrol (DES) Diethyl sulfate Diflunisal Diglycidyl ether Diglycidyl resorcinol ether (DGRE) Dihydroergotamine mesylate Dihydrosafrole Diisopropyl sulfate Di-isodecyl phthalate (DIDP) Diltiazem hydrochloride 3,3'-Dimethoxybenzidine (o Dianisidine) 3,3'-Dimethoxybenzidine dihydrochloride 3,3'-Dimethoxybenzidine-based dyes metabolized to 3,3'dimethoxybenzidine N,N-Dimethylacetamide 4-Dimethylaminoazobenzene trans -2-[(Dimethylamino)methylimino]5-[2-(5-nitro-2-furyl)vinyl]-1,3,4oxadiazole 7,12-Dimethylbenz(a)anthracene
Type of Toxicity
- 11 -
SQE FR
SQE AB
Date Listed
20-Apr-07 27-Feb-01
11-Jun-04 21-May-10 1-Jan-88
11-Jun-04
Chemical Dimethylcarbamoyl chloride 1,1-Dimethylhydrazine (UDMH) 1,2-Dimethylhydrazine Dimethyl sulfate Dimethylvinylchloride Di-n -butyl phthalate (DBP) Di-n -hexyl phthalate (DnHP) m -Dinitrobenzene o -Dinitrobenzene p -Dinitrobenzene 3,7-Dinitrofluoranthene 3,9-Dinitrofluoranthene 1,6-Dinitropyrene 1,8-Dinitropyrene 2,4-Dinitrotoluene 2,4-Dinitrotoluene 2,6-Dinitrotoluene 2,6-Dinitrotoluene Dinitrotoluene (technical grade) Dinitrotoluene mixture, 2,4-/2,6Dinocap Dinoseb Di-n -propyl isocinchomeronate (MGK Repellent 326) 1,4-Dioxane Diphenylhydantoin (Phenytoin) Diphenylhydantoin (Phenytoin) Diphenylhydantoin (Phenytoin), sodium salt Direct Black 38 (technical grade) Direct Blue 6 (technical grade) Direct Brown 95 (technical grade)
Listing Mechanism
CAS No.
cancer cancer cancer cancer cancer developmental, female, male female, male male male male cancer cancer cancer cancer cancer male cancer male female, male cancer developmental developmental, male cancer cancer cancer developmental
SQE LC SQE SQE SQE
79-44-7 57-14-7 540-73-8 77-78-1 513-37-1
AB AB
AB FR FR AB SQE SQE SQE
84-74-2 84-75-3 99-65-0 528-29-0 100-25-4 105735-71-5 22506-53-2 42397-64-8 42397-65-9 121-14-2 121-14-2 606-20-2 606-20-2 ----39300-45-3 88-85-7 136-45-8 123-91-1 57-41-0 57-41-0
2-Dec-05 2-Dec-05 1-Jul-90 1-Jul-90 1-Jul-90 26-Aug-97 26-Aug-97 1-Oct-90 1-Oct-90 1-Jul-88 20-Aug-99 1-Jul-95 20-Aug-99 20-Aug-99 1-May-96 1-Apr-90 1-Jan-89 1-May-96 1-Jan-88 1-Jan-88 1-Jul-87
cancer cancer cancer cancer
SQE SQE SQE SQE
630-93-3 1937-37-7 2602-46-2 16071-86-6
1-Jan-88 1-Jan-88 1-Jan-88 1-Oct-88
AB AB
138-93-2 2475-45-8 330-54-1
30-Mar-99 1-Oct-90 31-May-02
SQE
25316-40-9
1-Jul-87
FR
25316-40-9 564-25-0
29-Jan-99 1-Jul-90
Type of Toxicity
Disodium cyanodithioimidocarbonate Disperse Blue 1 Diuron Doxorubicin hydrochloride (Adriamycin)
developmental cancer cancer
Doxorubicin hydrochloride (Adriamycin) Doxycycline (internal use)
developmental, male developmental
AB AB AB AB AB
AB AB SQE AB
SQE AB AB
AB
cancer
- 12 -
FR
Date Listed 1-Jan-88 1-Oct-89 1-Jan-88 1-Jan-88 1-Jul-89
Chemical
Type of Toxicity
Listing Mechanism
CAS No.
Date Listed
Doxycycline calcium (internal use) Doxycycline hyclate (internal use) Doxycycline monohydrate (internal use)
developmental developmental
FR FR
94088-85-4 24390-14-5
1-Jan-92 1-Oct-91
developmental
FR
17086-28-1
1-Oct-91
Endrin
developmental
AB
72-20-8
15-May-98
Environmental tobacco smoke (ETS) Epichlorohydrin Epichlorohydrin Epoxiconazole Ergotamine tartrate
developmental cancer male cancer developmental
SQE
9-Jun-06 1-Oct-87 1-Sep-96 15-Apr-11 1-Apr-90
Erionite Estradiol 17B Estragole Estrogens, steroidal Estrogen-progestogen (combined) used as menopausal therapy Estrone
cancer cancer cancer cancer
--106-89-8 106-89-8 135319-73-2 379-79-3 12510-42-8; 66733-21-9 50-28-2 140-67-0 ---
1-Oct-88 1-Jan-88 29-Oct-99 19-Aug-05
--53-16-7
4-Nov-11 1-Jan-88
SQE SQE
7280-37-7 --57-63-6 536-33-4 13194-48-4 140-88-5 ---
26-Aug-97 29-Apr-11 1-Jan-88 26-Aug-97 27-Feb-01 1-Jul-89 1-Oct-87
SQE AB AB
FR SQE SQE SQE LC
Estropipate Ethanol in alcoholic beverages Ethinylestradiol Ethionamide Ethoprop Ethyl acrylate Ethyl alcohol in alcoholic beverages
cancer cancer cancer, developmental cancer cancer developmental cancer cancer developmental
Ethylbenzene Ethyl-tert-butyl ether
cancer male
AB LC
100-41-4 637-92-3
11-Jun-04 18-Dec-09
Ethyl dipropylthiocarbamate Ethyl-4,4'-dichlorobenzilate
developmental cancer
AB
AB
759-94-4 510-15-6
27-Apr-99 1-Jan-90
Ethylene dibromide
cancer developmental, male
FR
106-93-4
1-Jul-87
AB
106-93-4
15-May-98
cancer
SQE
107-06-2
1-Oct-87
developmental, male
SQE
110-80-5
1-Jan-89
Ethylene dibromide Ethylene dichloride (1,2Dichloroethane)
Ethylene glycol monoethyl ether
LC
SQE FR LC
SQE FR AB
- 13 -
Chemical
Ethylene glycol monoethyl ether acetate Ethylene glycol monomethyl ether Ethylene glycol monomethyl ether acetate Ethyleneimine Ethylene oxide Ethylene oxide Ethylene oxide Ethylene thiourea Ethylene thiourea 2-Ethylhexanoic acid Ethyl methanesulfonate
Type of Toxicity
developmental, male developmental, male developmental, male cancer cancer female developmental, male cancer developmental developmental cancer developmental, female cancer developmental
Etodolac Etoposide Etoposide Etoposide in combination with cisplatin and bleomycin cancer Etretinate developmental Fenoxaprop ethyl Fenoxycarb Filgrastim Fluazifop butyl Flunisolide Fluorouracil Fluoxymesterone Flurazepam hydrochloride Flurbiprofen Flutamide Fluticasone propionate Fluvalinate Folpet Formaldehyde (gas) 2-(2-Formylhydrazino)-4-(5-nitro-2furyl)thiazole Fumonisin B1 Furan
Listing Mechanism
CAS No.
AB
111-15-9
1-Jan-93
SQE
109-86-4
1-Jan-89
AB SQE FR LC
110-49-6 151-56-4 75-21-8 75-21-8
1-Jan-93 1-Jan-88 1-Jul-87 27-Feb-87
LC
75-21-8 96-45-7 96-45-7 149-57-5 62-50-0
7-Aug-09 1-Jan-88 1-Jan-93 7-Aug-09 1-Jan-88
41340-25-4 33419-42-0 33419-42-0
20-Aug-99 4-Nov-11 1-Jul-90
SQE
--54350-48-0
4-Nov-11 1-Jul-87
AB AB FR AB
66441-23-4 72490-01-8 121181-53-1 69806-50-4
26-Mar-99 2-Jun-00 27-Feb-01 6-Nov-98
FR
3385-03-3 51-21-8 76-43-7 1172-18-5
15-May-98 1-Jan-89 1-Apr-90 1-Oct-92
5104-49-4 13311-84-7 80474-14-2 69409-94-5 133-07-3 50-00-0
20-Aug-99 1-Jul-90 15-May-98 6-Nov-98 1-Jan-89 1-Jan-88 1-Jan-88 14-Nov-03
AB SQE LC
SQE FR LC
FR LC
developmental cancer developmental developmental developmental, female developmental developmental developmental developmental, female developmental developmental developmental cancer cancer
SQE FR FR FR
FR FR AB
SQE SQE
cancer cancer
SQE AB
3570-75-0 116355-83-0
cancer
AB
110-00-9
- 14 -
Date Listed
1-Oct-93
Chemical
Listing Mechanism
CAS No.
AB AB SQE
67-45-8 60568-05-0 79748-81-5
1-Jan-90 1-Jan-90 1-Jul-95
LC
1303-00-0
1-Aug-08
FR
82410-32-0
26-Aug-97
FR
107910-75-8
26-Aug-97
cancer cancer female, male
AB FR FR
--25812-30-0 25812-30-0
1-Oct-90 22-Dec-00 20-Aug-99
cancer
AB
---
1-Jul-90
AB
67730-11-4
1-Jan-90
AB SQE AB
67730-10-3 765-34-4 556-52-5
1-Jan-90 1-Jan-88 1-Jul-90
FR
AB
65807-02-5 126-07-8
26-Aug-97 1-Jan-90
SQE
16568-02-8
1-Jan-88
FR
23092-17-3 66852-54-8
1-Jul-90 20-Aug-99
52-86-8 151-67-7 2784-94-3 76-44-8 76-44-8 1024-57-3
29-Jan-99 1-Sep-96 1-Jul-89 1-Jul-88 20-Aug-99 1-Jul-88
--118-74-1 118-74-1 87-68-3
9-Jul-04 1-Oct-87 1-Jan-89 3-May-11
Type of Toxicity
Furazolidone Furmecyclox Fusarin C
cancer cancer cancer
Gallium arsenide
cancer cancer, developmental, male developmental, male
Ganciclovir Ganciclovir sodium Gasoline engine exhaust (condensates/extracts) Gemfibrozil Gemfibrozil Glass wool fibers (inhalable and biopersistent)
Glu-P-1 (2-Amino-6-methyldipyrido[1,2a:3',2'-d]imidazole) cancer Glu-P-2 (2-Aminodipyrido[1,2-a:3',2'd]imidazole) cancer Glycidaldehyde cancer Glycidol cancer developmental, Goserelin acetate female, male Griseofulvin cancer Gyromitrin (Acetaldehyde methylformylhydrazone) cancer Halazepam Halobetasol propionate Haloperidol Halothane HC Blue 1 Heptachlor Heptachlor Heptachlor epoxide Herbal remedies containing plant species of the genus Aristolochia Hexachlorobenzene Hexachlorobenzene Hexachlorobutadiene
developmental developmental developmental, female developmental cancer cancer developmental cancer cancer cancer developmental cancer
FR FR
FR SQE SQE AB
SQE LC
SQE SQE AB
- 15 -
Date Listed
Chemical Hexachlorocyclohexane (technical grade) Hexachlorocyclohexane (alpha isomer) Hexachlorocyclohexane (beta isomer) Hexachlorocyclohexane (gamma isomer) Hexachlorodibenzodioxin Hexachloroethane 2,4-Hexadienal (89% trans, trans isomer; 11% cis, trans isomer) Hexafluoroacetone Hexamethylphosphoramide Hexamethylphosphoramide Histrelin acetate Hydramethylnon Hydrazine Hydrazine sulfate Hydrazobenzene (1,2Diphenylhydrazine) 1-Hydroxyanthraquinone Hydroxyurea
Idarubicin hydrochloride Ifosfamide Iodine-131 Imazalil Indeno [1,2,3-cd]pyrene Indium phosphide IQ (2-Amino-3-methylimidazo[4,5-f] quinoline) Iprodione
Iprovalicarb Iron dextran complex Isobutyl nitrite Isoprene Isosafrole Delisted December 8, 2006 [Click here for the basis for delisting]
Isotretinoin
Listing Mechanism
CAS No.
cancer
SQE
---
1-Oct-87
cancer cancer
SQE AB
34465-46- 8 67-72-1
1-Apr-88 1-Jul-90
AB LC
--684-16-2 680-31-9 680-31-9 ---
Type of Toxicity
cancer male cancer male developmental developmental, male cancer cancer cancer cancer developmental
SQE AB FR AB
SQE SQE SQE
67485-29-4 302-01-2 10034-93-2
Date Listed
4-Mar-05 1-Aug-08 1-Jan-88 1-Oct-94 15-May-98 5-Mar-99 1-Jan-88 1-Jan-88
122-66-7 129-43-1 127-07-1
1-Jan-88 27-May-05 1-May-97
AB
57852-57-0 3778-73-2 10043-66-0 35554-44-0 193-39-5 22398-80-7
20-Aug-99 1-Jul-90 1-Jan-89 20-May-11 1-Jan-88 27-Feb-01
cancer cancer
AB AB
76180-96-6 36734-19-7
1-Apr-90 1-May-96
cancer cancer cancer cancer
AB
SQE AB AB
140923-17-7 & 140923-25-7 9004-66-4 542-56-3 78-79-5
1-Jun-07 1-Jan-88 1-May-96 1-May-96
cancer developmental
LC SQE
120-58-1 4759-48-2
1-Oct-89 1-Jul-87
LC FR
developmental, male developmental developmental cancer cancer cancer
- 16 -
FR
FR SQE AB
SQE
Chemical
Type of Toxicity
Listing Mechanism
CAS No.
Date Listed
Isoxaflutole
cancer
AB
141112-29-0
22-Dec-00
Kresoxim-methyl
cancer
AB
143390-89-0
3-Feb-12
Lactofen Lasiocarpine
cancer cancer developmental, female, male cancer
SQE SQE
77501-63-4 303-34-4
1-Jan-89 1-Apr-88
LC AB
-----
27-Feb-87 1-Oct-92
cancer cancer cancer cancer developmental, female, male developmental female
SQE SQE LC LC
301-04-2 7446-27-7 1335-32-6 ---
1-Jan-88 1-Apr-88 1-Oct-89 29-Apr-11
FR FR FR
74381-53-6 59-92-7 797-63-7
26-Aug-97 29-Jan-99 15-May-98
cancer developmental developmental developmental developmental developmental cancer
LC
--330-55-2 554-13-2 919-16-4 846-49-1 75330-75-5 52-76-6
1-Oct-89 19-Mar-99 1-Jan-91 1-Jan-91 1-Jul-90 1-Oct-92 27-Feb-01
24382-04-5 8018-01-7 12427-38-2 ---
29-Apr-11 1-Jan-90 1-Jan-90 19-Jun-09 1-Jan-90 20-Aug-99 1-Jan-90 1-Apr-90 1-Jan-91
Lead Lead and lead compounds Lead Lead acetate Lead phosphate Lead subacetate Leather dust Leuprolide acetate Levodopa Levonorgestrel implants Lindane and other hexachlorocyclohexane isomers Linuron Lithium carbonate Lithium citrate Lorazepam Lovastatin Lynestrenol Malonaldehyde, sodium salt Mancozeb Maneb Marijuana smoke Me-A-alpha-C (2-Amino-3-methyl-9Hpyrido[2,3-b]indole) Mebendazole Medroxyprogesterone acetate Medroxyprogesterone acetate Megestrol acetate MeIQ (2-Amino-3,4dimethylimidazo[4,5-f]quinoline) MeIQx (2-Amino-3,8dimethylimidazo[4,5-f]quinoxaline) Melphalan Melphalan Menotropins
AB
FR FR FR FR AB
cancer cancer cancer cancer
AB
AB AB SQE
cancer developmental cancer developmental developmental
AB AB FR FR
68006-83-7 31431-39-7 71-58-9 71-58-9 595-33-5
cancer
AB
77094-11-2
1-Oct-94
cancer cancer developmental developmental
AB LC FR FR
77500-04-0 148-82-3 148-82-3 9002-68-0
1-Oct-94 27-Feb-87 1-Jul-90 1-Apr-90
FR
- 17 -
Chemical Mepanipyrim Meprobamate Mercaptopurine Mercury and mercury compounds Merphalan Mestranol Metam potassium Methacycline hydrochloride Metham sodium Metham sodium Methazole Methimazole Methotrexate Methotrexate sodium 5-Methoxypsoralen with ultraviolet A therapy 8-Methoxypsoralen with ultraviolet A therapy 2-Methylaziridine (Propyleneimine) Methylazoxymethanol Methylazoxymethanol acetate Methyl bromide, as a structural fumigant Methyl carbamate Methyl chloride Methyl chloride 3-Methylcholanthrene 5-Methylchrysene 4,4'-Methylene bis(2-chloroaniline) 4,4'-Methylene bis(N,Ndimethyl)benzenamine 4,4'-Methylene bis(2-methylaniline) 4,4'-Methylenedianiline
Type of Toxicity cancer developmental developmental developmental cancer cancer cancer developmental cancer developmental developmental developmental developmental developmental
Listing Mechanism
CAS No.
Date Listed
FR SQE FR
110235-47-7 57-53-4 6112-76-1 --531-76-0 72-33-3 137-41-7 3963-95-9 137-42-8 137-42-8 20354-26-1 60-56-0 59-05-2 15475-56-6
cancer
SQE
484-20-8
1-Oct-88
cancer cancer cancer cancer
LC SQE SQE SQE
298-81-7 75-55-8 590-96-5 592-62-1
27-Feb-87 1-Jan-88 1-Apr-88 1-Apr-88
FR
1-Jan-93 15-May-98 10-Mar-00 7-Aug-09 1-Jan-90 1-Apr-88 1-Jul-87 1-Oct-89 1-Apr-88 1-Jan-88
AB
FR FR AB SQE SQE AB
FR AB AB AB
1-Jul-08 1-Jan-92 1-Jul-90 1-Jul-90 1-Apr-88 1-Apr-88 31-Dec-10 1-Jan-91 6-Nov-98 15-May-98 1-Dec-99 1-Jul-90 1-Jan-89 1-Apr-90
developmental cancer developmental male cancer cancer cancer
AB SQE FR
74-83-9 598-55-0 74-87-3 74-87-3 56-49-5 3697-24-3 101-14-4
cancer cancer cancer
LC SQE SQE
101-61-1 838-88-0 101-77-9
4,4'-Methylenedianiline dihydrochloride cancer Methyleugenol cancer Methylhydrazine and its salts cancer
SQE
13552-44-8 93-15-2 ---
1-Jan-88 16-Nov-01 1-Jul-92
822-36-6 74-88-4 108-10-1
7-Jan-11 1-Apr-88 4-Nov-11
Methylhydrazine Methylhydrazine sulfate 4-Methylimidazole Methyl iodide Methyl isobutyl ketone
AB AB LC
AB
AB
cancer cancer cancer
AB
SQE LC - 18 -
Chemical
Methyl isocyanate (MIC)
Type of Toxicity developmental, female
Listing Mechanism
CAS No.
SQE
624-83-9
12-Nov-10
LC
17-Feb-12 1-Jul-87 1-May-96 1-Apr-88 7-Aug-09
Date Listed
Methyl isopropyl ketone Methyl mercury Methylmercury compounds Methyl methanesulfonate Methyl n-butyl ketone 2-Methyl-1-nitroanthraquinone (of uncertain purity)
developmental developmental cancer cancer male
SQE AB SQE LC
563-80-4 ----66-27-3 591-78-6
cancer
SQE
129-15-7
1-Apr-88
N-Methyl-N'-nitro-N-nitrosoguanidine N-Methylolacrylamide
cancer cancer
SQE AB
70-25-7 924-42-5
1-Apr-88 1-Jul-90
N-Methylpyrrolidone
developmental
AB
872-50-4
15-Jun-01
α-Methyl styrene Methyltestosterone Methylthiouracil Metiram Metiram Metronidazole Michler's ketone Midazolam hydrochloride Minocycline hydrochloride (internal use) Mirex Misoprostol Mitomycin C Mitoxantrone hydrochloride
female developmental cancer cancer developmental cancer cancer developmental
LC
SQE SQE FR
98-83-9 58-18-4 56-04-2 9006-42-2 9006-42-2 443-48-1 90-94-8 59467-96-8
29-Jul-11 1-Apr-90 1-Oct-89 1-Jan-90 30-Mar-99 1-Jan-88 1-Jan-88 1-Jul-90
FR SQE FR SQE FR
13614-98-7 2385-85-5 59122-46-2 50-07-7 70476-82-3
1-Jan-92 1-Jan-88 1-Apr-90 1-Apr-88 1-Jul-90
AB
2212-67-1
11-Dec-09
cancer cancer
AB AB
71526-07-3 121776-33-8
22-Mar-11 22-Mar-11
cancer cancer
SQE
SQE
96-24-2 315-22-0
8-Oct-10 1-Apr-88
LC
113803-47-7
4-Nov-11
Molinate MON 4660 (dichloroacetyl-1-oxa-4azaspiro(4,5)-decane MON 13900 (furilazole) 3-Monochloropropane-1,2-diol (3MCDP) Monocrotaline
FR LC AB AB
developmental cancer developmental cancer developmental developmental, female, male
MOPP (vincristine-prednisone-nitrogen mustard-procarbazine mixture) cancer
- 19 -
Listing Mechanism
CAS No.
cancer cancer
SQE LC
139-91-3 505-60-2
1-Apr-88 27-Feb-87
SQE
77439-76-0
22-Dec-00
Myclobutanil
cancer developmental, male
AB
88671-89-0
16-Apr-99
Nabam Nafarelin acetate Nafenopin Nalidixic acid Naphthalene 1-Naphthylamine 2-Naphthylamine Neomycin sulfate (internal use) Netilmicin sulfate Nickel (Metallic) Nickel acetate Nickel carbonate Nickel carbonyl Nickel carbonyl Nickel compounds
developmental developmental cancer cancer cancer cancer cancer developmental developmental cancer cancer cancer cancer developmental cancer
AB
30-Mar-99 1-Apr-90 1-Apr-88 15-May-98 19-Apr-02 1-Oct-89 27-Feb-87 1-Oct-92 1-Jul-90 1-Oct-89 1-Oct-89 1-Oct-89 1-Oct-87 1-Sep-96 7-May-04
Nickel hydroxide Nickelocene Nickel oxide Nickel refinery dust from the pyrometallurgical process Nickel subsulfide Nicotine
cancer cancer cancer
LC LC LC
142-59-6 86220-42-0 3771-19-5 389-08-2 91-20-3 134-32-7 91-59-8 1405-10-3 56391-57-2 7440-02-0 373-02-4 3333-67-3 13463-39-3 13463-39-3 --12054-48-7; 12125-56-3 1271-28-9 1313-99-1
cancer cancer developmental developmental, female, male developmental cancer cancer developmental cancer
SQE SQE FR
--12035-72-2 54-11-5
1-Oct-87 1-Oct-87 1-Apr-90
FR FR
SQE
21829-25-4 66085-59-4 61-57-4 1929-82-4 1929-82-4 139-13-9
29-Jan-99 24-Apr-01 1-Apr-88 5-Oct-05 30-Mar-99 1-Jan-88
cancer cancer
SQE SQE
18662-53-8 602-87-9
1-Apr-89 1-Apr-88
LC
99-59-2
1-Oct-89
Chemical 5-(Morpholinomethyl)-3-[(5nitrofurfurylidene)-amino]-2oxazolidinone Mustard Gas MX (3-chloro-4-dichloromethyl-5hydroxy-2(5H)-furanone)
Nifedipine Nimodipine Niridazole Nitrapyrin Nitrapyrin Nitrilotriacetic acid Nitrilotriacetic acid, trisodium salt monohydrate 5-Nitroacenaphthene
Type of Toxicity
FR SQE AB AB
LC LC FR FR LC LC LC SQE AB LC
5-Nitro-o-anisidine Delisted December 8, 2006 [Click here for the basis for delisting] cancer - 20 -
SQE AB AB
Date Listed
1-Oct-89 1-Oct-89 1-Oct-89
Chemical
Type of Toxicity
o -Nitroanisole Nitrobenzene Nitrobenzene 4-Nitrobiphenyl 6-Nitrochrysene Nitrofen (technical grade) 2-Nitrofluorene Nitrofurantoin Nitrofurazone 1-[(5-Nitrofurfurylidene)-amino]-2imidazolidinone N-[4-(5-Nitro-2-furyl)-2thiazolyl]acetamide
cancer cancer male cancer cancer cancer cancer male cancer
Listing Mechanism AB
CAS No.
Date Listed
SQE AB SQE AB AB AB
91-23-6 98-95-3 98-95-3 92-93-3 7496-02-8 1836-75-5 607-57-8 67-20-9 59-87-0
1-Oct-92 26-Aug-97 30-Mar-10 1-Apr-88 1-Oct-90 1-Jan-88 1-Oct-90 1-Apr-91 1-Jan-90
cancer
SQE
555-84-0
1-Apr-88
cancer
SQE
531-82-8
1-Apr-88
Nitrogen mustard (Mechlorethamine) Nitrogen mustard (Mechlorethamine) Nitrogen mustard hydrochloride (Mechlorethamine hydrochloride) Nitrogen mustard hydrochloride (Mechlorethamine hydrochloride) Nitrogen mustard N-oxide Nitrogen mustard N-oxide hydrochloride Nitromethane 2-Nitropropane 1-Nitropyrene 4-Nitropyrene N-Nitrosodiethanolamine N-Nitrosodiethylamine N-Nitrosodimethylamine N-Nitrosodi-n -butylamine N-Nitrosodi-n -propylamine p -Nitrosodiphenylamine N-Nitrosodiphenylamine
cancer developmental
SQE SQE
51-75-2 51-75-2
1-Jan-88 1-Jan-89
cancer
SQE
55-86-7
1-Apr-88
developmental cancer
FR SQE
55-86-7 126-85-2
1-Jul-90 1-Apr-88
cancer cancer cancer cancer cancer cancer cancer cancer cancer cancer cancer cancer
SQE SQE AB AB SQE SQE SQE SQE SQE SQE SQE
302-70-5 75-52-5 79-46-9 5522-43-0 57835-92-4 1116-54-7 55-18-5 62-75-9 924-16-3 621-64-7 156-10-5 86-30-6
1-Apr-88 1-May-97 1-Jan-88 1-Oct-90 1-Oct-90 1-Jan-88 1-Oct-87 1-Oct-87 1-Oct-87 1-Jan-88 1-Jan-88 1-Apr-88
3-(N-Nitrosomethylamino) propionitrile 4-(N-Nitrosomethylamino)-1-(3pyridyl)1-butanone N-Nitrosomethylethylamine N-Nitrosomethylvinylamine N-Nitrosomorpholine N-Nitroso-N-ethylurea N-Nitroso-N-methylurea N-Nitroso-N-methylurethane N-Nitrosonornicotine
cancer
AB
60153-49-3
1-Apr-90
cancer cancer cancer cancer cancer cancer cancer cancer
AB LC SQE SQE SQE SQE SQE SQE
64091-91-4 10595-95-6 4549-40-0 59-89-2 759-73-9 684-93-5 615-53-2 16543-55-8
1-Apr-90 1-Oct-89 1-Jan-88 1-Jan-88 1-Oct-87 1-Oct-87 1-Apr-88 1-Jan-88
AB AB
AB
- 21 -
Chemical
Type of Toxicity
Listing Mechanism
N-Nitrosopiperidine N-Nitrosopyrrolidine N-Nitrososarcosine o -Nitrotoluene Nitrous oxide Norethisterone (Norethindrone) Norethisterone (Norethindrone) Norethisterone acetate (Norethindrone acetate) Norethisterone (Norethindrone) /Ethinyl estradiol Norethisterone (Norethindrone) /Mestranol Norethynodrel Norgestrel
cancer cancer cancer cancer developmental cancer developmental
SQE SQE SQE
developmental
FR
developmental
FR
developmental cancer developmental
FR
Ochratoxin A Oil Orange SS Oral contraceptives, combined Oral contraceptives, sequential Oryzalin Oxadiazon Oxadiazon Oxazepam Oxazepam p,p'-Oxybis(benzenesulfonyl hydrazide) Oxydemeton methyl Oxymetholone Oxymetholone Oxytetracycline (internal use) (internal hydrochloride use) Oxythioquinox (Chinomethionat) Oxythioquinox (Chinomethionat)
cancer cancer cancer cancer cancer cancer developmental cancer developmental
AB SQE LC LC
developmental female, male cancer developmental developmental developmental cancer developmental
LC AB
CAS No.
Date Listed
100-75-4 930-55-2 13256-22-9 88-72-2 10024-97-2 68-22-4 68-22-4
1-Jan-88 1-Oct-87 1-Jan-88 15-May-98 1-Aug-08 1-Oct-89 1-Apr-90
51-98-9 68-22-4 57-63-6 68-22-4 72-33-3 68-23-5 6533-00-2
1-Oct-91
1-Apr-90 27-Feb-01 1-Apr-90
303-47-9 2646-17-5 ----19044-88-3 19666-30-9 19666-30-9 604-75-1 604-75-1
1-Jul-90 1-Apr-88 1-Oct-89 1-Oct-89 12-Sep-08 1-Jul-91 15-May-98 1-Oct-94 1-Oct-92
AB AB
80-51-3 301-12-2 434-07-1 434-07-1 79-57-2 2058-46-0 2439-01-2 2439-01-2
7-Aug-09 6-Nov-98 1-Jan-88 1-May-97 1-Jan-91 1-Oct-91 20-Aug-99 6-Nov-98
Paclitaxel
developmental, female, male
FR
33069-62-4
26-Aug-97
Palygorskite fibers (> 5mm in length) Panfuran S Paramethadione Penicillamine Pentachlorophenol Pentobarbital sodium
cancer cancer developmental developmental cancer developmental
AB
SQE FR FR AB FR
12174-11-7 794-93-4 115-67-3 52-67-5 87-86-5 57-33-0
28-Dec-99 1-Jan-88 1-Jul-90 1-Jan-91 1-Jan-90 1-Jul-90
AB LC
LC FR
AB
FR
AB
SQE AB
AB FR
SQE FR
FR FR
- 22 -
1-Apr-90
Chemical Pentostatin Phenacemide Phenacetin Phenazopyridine Phenazopyridine hydrochloride Phenesterin Phenobarbital Phenolphthalein Phenoxybenzamine Phenoxybenzamine hydrochloride Phenprocoumon o -Phenylenediamine and its salts o -Phenylenediamine o -Phenylenediamine dihydochloride Phenyl glycidyl ether Phenyl glycidyl ether Phenylhydrazine and its salts Phenylhydrazine Phenylhydrazine hydrochloride o -Phenylphenate, sodium o -Phenylphenol Phenylphosphine PhiP(2-Amino-1-methyl-6phenylimidazol[4,5-b]pyridine) Pimozide Pipobroman Pirimicarb Plicamycin Polybrominated biphenyls Polybrominated biphenyls Polychlorinated biphenyls Polychlorinated biphenyls Polychlorinated biphenyls (containing 60 or more percent percent chlorine by molecular weight) Polychlorinated dibenzo-p -dioxins Polychlorinated dibenzofurans Polygeenan Ponceau MX Ponceau 3R Potassium bromate Potassium dimethyldithiocarbamate Pravastatin sodium
Type of Toxicity developmental developmental cancer cancer cancer cancer cancer cancer cancer cancer developmental cancer
Listing Mechanism FR FR LC SQE SQE SQE AB AB
SQE SQE FR AB
cancer male cancer
AB
cancer cancer developmental cancer developmental, female developmental cancer developmental cancer developmental cancer developmental
AB
LC
AB
cancer cancer cancer cancer cancer cancer cancer developmental developmental
AB LC
AB FR
FR AB
FR SQE AB LC SQE
SQE FR FR SQE SQE SQE AB AB FR - 23 -
CAS No. 53910-25-1 63-98-9 62-44-2 94-78-0 136-40-3 3546-10-9 50-06-6 77-09-8 59-96-1 63-92-3 435-97-2 95-54-5
Date Listed 1-Sep-96 1-Jul-90 1-Oct-89 1-Jan-88 1-Jan-88 1-Jul-89 1-Jan-90 15-May-98 1-Apr-88 1-Apr-88 1-Oct-92 15-May-98
122-60-1 122-60-1 ---
1-Oct-90 7-Aug-09 1-Jul-92
132-27-4 90-43-7 638-21-1 105650-23-5
1-Jan-90 4-Aug-00 7-Aug-09 1-Oct-94
2062-78-4 54-91-1 23103-98-2 18378-89-7 ---------
20-Aug-99 1-Jul-90 1-Jul-08 1-Apr-90 1-Jan-88 1-Oct-94 1-Oct-89 1-Jan-91
------53973-98-1 3761-53-3 3564-09-8 7758-01-2 128-03-0 81131-70-6
1-Jan-88 1-Oct-92 1-Oct-92 1-Jan-88 1-Apr-88 1-Apr-88 1-Jan-90 30-Mar-99 3-Mar-00
Chemical
Type of Toxicity
Prednisolone sodium phosphate Primidone Procarbazine Procarbazine hydrochloride Procarbazine hydrochloride Procymidone Progesterone Pronamide Propachlor 1,3-Propane sultone Propargite Propargite beta-Propiolactone Propoxur Propylene glycol mono-t -butyl ether Propylene oxide Propylthiouracil Propylthiouracil Pymetrozine Pyridine Pyrimethamine
developmental cancer cancer cancer developmental cancer cancer cancer cancer cancer cancer developmental cancer cancer cancer cancer cancer developmental cancer cancer developmental
Quazepam Quinoline and its strong acid salts Quizalofop-ethyl Radionuclides Reserpine Residual (heavy) fuel oils Resmethrin Resmethrin Retinol/retinyl esters, when in daily dosages in excess of 10,000 IU, or 3,000 retinol equivalents. (NOTE: Retinol/retinyl esters are required and essential for maintenance of normal reproductive function. The recommended daily level during pregnancy is 8,000 IU.) Ribavirin Ribavirin Riddelliine Rifampin
Listing Mechanism
CAS No.
Date Listed
AB AB FR
125-02-0 125-33-7 671-16-9 366-70-1 366-70-1 32809-16-8 57-83-0 23950-58-5 1918-16-7 1120-71-4 2312-35-8 2312-35-8 57-57-8 114-26-1 57018-52-7 75-56-9 51-52-5 51-52-5 123312-89-0 110-86-1 58-14-0
20-Aug-99 20-Aug-99 1-Jan-88 1-Jan-88 1-Jul-90 1-Oct-94 1-Jan-88 1-May-96 27-Feb-01 1-Jan-88 1-Oct-94 15-Jun-99 1-Jan-88 11-Aug-06 11-Jun-04 1-Oct-88 1-Jan-88 1-Jul-90 22-Mar-11 17-May-02 29-Jan-99
developmental cancer male
FR SQE SQE
36735-22-5 --76578-14-8
26-Aug-97 24-Oct-97 24-Dec-99
cancer cancer cancer cancer developmental
SQE LC AB
--50-55-5 --10453-86-8 10453-86-8
1-Jul-89 1-Oct-89 1-Oct-90 1-Jul-08 6-Nov-98
developmental developmental male cancer developmental, female
SQE FR FR LC
--36791-04-5 36791-04-5 23246-96-0
1-Jul-89 1-Apr-90 27-Feb-01 3-Dec-04
FR
13292-46-1
27-Feb-01
FR AB
SQE SQE FR AB SQE AB AB
SQE AB AB
SQE AB AB
SQE SQE FR
AB AB
- 24 -
Listing Mechanism
CAS No.
LC
81-07-2
SQE SQE LC FR LC AB
128-44-9 94-59-7 --309-43-3 7446-34-6 --68308-34-9
SQE
---
AB AB
128-04-1 62-74-8
30-Mar-99 6-Nov-98
LC
---
27-Feb-87
AB FR FR
148477-71-8 52-01-7 10418-03-8 10048-13-2 3810-74-0
8-Oct-10 1-May-97 1-May-97 1-Apr-88 1-Jan-91
18883-66-4 18883-66-4
20-Aug-99 1-Jan-88
SQE SQE
--96-09-3 95-06-7
14-Mar-03 1-Oct-88 1-Jan-88
AB
599-79-1
15-May-98
Sulfasalazine (salicylazosulfapyridine) male Sulfur dioxide developmental developmental, Sulindac female
FR SQE
599-79-1 7446-09-5
29-Jan-99 29-Jul-11
FR
38194-50-2
29-Jan-99
Talc containing asbestiform fibers Tamoxifen and its salts
AB SQE
--10540-29-1
1-Apr-90 1-Sep-96
Chemical
Saccharin Delisted April 6, 2001 [Click here for the basis for delisting]
Type of Toxicity
cancer
Saccharin, sodium Delisted January 17, 2003 [Click here for the basis for delisting] cancer
Safrole Salted fish, Chinese-style Secobarbital sodium Selenium sulfide Sermorelin acetate Shale-oils Silica, crystalline (airborne particles of respirable size)
cancer cancer developmental cancer developmental cancer
FR
cancer
Sodium dimethyldithiocarbamate developmental Sodium fluoroacetate male Soots, tars, and mineral oils (untreated and mildly treated oils and used engine oils) cancer Spirodiclofen Spironolactone Stanozolol Sterigmatocystin Streptomycin sulfate
cancer cancer cancer cancer developmental
SQE
developmental, female, male cancer
Streptozocin (streptozotocin) Streptozotocin (streptozocin) Strong inorganic acid mists containing sulfuric acid cancer Styrene oxide cancer Sulfallate cancer
FR
SQE AB
Sulfasalazine (salicylazosulfapyridine) cancer
cancer cancer - 25 -
Date Listed
1-Oct-89
1-Jan-88 1-Jan-88 29-Apr-11 1-Oct-92 1-Oct-89 20-Aug-99 1-Apr-90 1-Oct-88
Chemical Tamoxifen citrate Temazepam Teniposide Terbacil Terrazole Testosterone and its esters Testosterone cypionate Testosterone enanthate 2,3,7,8-Tetrachlorodibenzo-p -dioxin (TCDD) 2,3,7,8-Tetrachlorodibenzo-p -dioxin (TCDD) 1,1,2,2-Tetrachloroethane Tetrachloroethylene (Perchloroethylene) p-a,a,a- Tetrachlorotoluene Tetracycline (internal use) Tetracyclines (internal use) Tetracycline hydrochloride (internal use) Tetrafluoroethylene Tetranitromethane Thalidomide Thioacetamide 4,4'-Thiodianiline Thiodicarb Thioguanine Thiophanate methyl Thiouracil Thiourea Thorium dioxide Titanium dioxide (airborne, unbound particles of respirable size) Tobacco, oral use of smokeless products Tobacco smoke Tobacco smoke (primary) Tobramycin sulfate Toluene Toluene Toluene diisocyanate o -Toluidine o -Toluidine hydrochloride
Type of Toxicity developmental developmental developmental developmental cancer cancer developmental developmental cancer
Listing Mechanism FR FR FR
CAS No.
Date Listed
AB SQE FR FR
54965-24-1 846-50-4 29767-20-2 5902-51-2 2593-15-9 58-22-0 58-20-8 315-37-7
1-Jul-90 1-Apr-90 1-Sep-96 18-May-99 1-Oct-94 1-Apr-88 1-Oct-91 1-Apr-90
SQE
1746-01-6
1-Jan-88
developmental cancer
AB AB
1746-01-6 79-34-5
1-Apr-91 1-Jul-90
cancer cancer developmental developmental
SQE AB FR FR
127-18-4 5216-25-1 60-54-8 ---
1-Apr-88 1-Jan-90 1-Oct-91 1-Oct-92
developmental cancer cancer developmental cancer cancer cancer developmental female, male cancer cancer cancer
FR
SQE LC
64-75-5 116-14-3 509-14-8 50-35-1 62-55-5 139-65-1 59669-26-0 154-42-7 23564-05-8 141-90-2 62-56-6 1314-20-1
1-Jan-91 1-May-97 1-Jul-90 1-Jul-87 1-Jan-88 1-Apr-88 20-Aug-99 1-Jul-90 18-May-99 11-Jun-04 1-Jan-88 27-Feb-87
LC
---
2-Sep-11
SQE SQE
-----
1-Apr-88 1-Apr-88
SQE FR SQE
--49842-07-1 108-88-3 108-88-3 26471-62-5 95-53-4 636-21-5
1-Apr-88 1-Jul-90 1-Jan-91 7-Aug-09 1-Oct-89 1-Jan-88 1-Jan-88
AB
AB
AB SQE SQE SQE AB
FR AB AB
cancer cancer cancer developmental, female, male developmental developmental female cancer cancer cancer - 26 -
LC
LC SQE SQE
Chemical
para-Toluidine Delisted October 29, 1999 [Click here for the basis for delisting]
Toxaphene (Polychlorinated camphenes) Toxins derived from Fusarium moniliforme (Fusarium verticillioides) Treosulfan
Listing Mechanism
CAS No.
cancer
AB
106-49-0
1-Jan-90
cancer
SQE
8001-35-2
1-Jan-88
LC
--299-75-2
7-Aug-09 27-Feb-87 30-Mar-99 1-Apr-90
Type of Toxicity
Date Listed
cancer cancer developmental, female, male developmental
FR
43121-43-3 28911-01-5
cancer
AB
78-48-8
25-Feb-11
Tributyltin methacrylate Trichlormethine (Trimustine hydrochloride)
developmental
AB
2155-70-6
1-Dec-99
cancer
AB
817-09-4
1-Jan-92
Trichloroethylene 2,4,6-Trichlorophenol 1,2,3-Trichloropropane Trientine hydrochloride Triforine 1,3,5-Triglycidyl-s-triazinetrione Trilostane Trimethadione 2,4,5-Trimethylaniline and its strong acid salts Trimethyl phosphate Trimetrexate glucuronate 2,4.6-Trinitrotoluene (TNT) Triphenyltin hydroxide Triphenyltin hydroxide
cancer cancer cancer developmental developmental male developmental developmental
SQE SQE AB
79-01-6 88-06-2 96-18-4 38260-01-4 26644-46-2 2451-62-9 13647-35-3 127-48-0
1-Apr-88 1-Jan-88 1-Oct-92 27-Feb-01 18-Jun-99 7-Aug-09 1-Apr-90 1-Jan-91
cancer cancer developmental cancer cancer developmental
SQE
AB
--512-56-1 82952-64-5 118-96-7 76-87-9 76-87-9
24-Oct-97 1-May-96 26-Aug-97 19-Dec-08 1-Jul-92 18-Mar-02
cancer
LC
68-76-8
1-Oct-89
cancer cancer cancer
SQE AB SQE
52-24-4 115-96-8 126-72-7
1-Jan-88 1-Apr-92 1-Jan-88
cancer cancer cancer
SQE
SQE SQE
13674-87-8 62450-06-0 62450-07-1
28-Oct-11 1-Apr-88 1-Apr-88
Triadimefon Triazolam S,S,S-Tributyl phosphorotrithioate (Tribufos, DEF)
Tris(aziridinyl)-p-benzoquinone (Triaziquone) Delisted December 8, 2006 [Click here for the basis for delisting]
Tris(1-aziridinyl)phosphine sulfide (Thiotepa) Tris(2-chloroethyl) phosphate Tris(2,3-dibromopropyl)phosphate Tris(1,3-dichloro-2-propyl) phosphate (TDP) Trp-P-1 (Tryptophan-P-1) Trp-P-2 (Tryptophan-P-2)
LC AB
FR AB LC
FR FR
AB FR SQE
AB
- 27 -
Chemical
Type of Toxicity
Listing Mechanism
CAS No.
LC
72-57-1
1-Oct-89
Date Listed
Trypan blue (commercial grade)
cancer
Unleaded gasoline (wholly vaporized) Uracil mustard
cancer cancer developmental, female, male cancer developmental developmental
SQE SQE
--66-75-1
1-Apr-88 1-Apr-88
FR SQE AB FR
66-75-1 51-79-6 51-79-6 97048-13-0
1-Jan-92 1-Jan-88 1-Oct-94 1-Apr-90
developmental
SQE
99-66-1
1-Jul-87
cancer developmental cancer developmental developmental cancer cancer cancer female, male
AB
LC
1314-62-1 143-67-9 50471-44-8 50471-44-8 2068-78-2 593-60-2 75-01-4 100-40-3 100-40--3
cancer
AB
106-87-6
1-Jul-90
female, male cancer
LC AB
106-87-6 75-02-5
1-Aug-08 1-May-97
AB
79-00-5
1-Oct-90
SQE LC
81-81-2 ---
1-Jul-87 18-Dec-09 1-Jan-91
Uracil mustard Urethane (Ethyl carbamate) Urethane (Ethyl carbamate) Urofollitropin Valproate (Valproic acid) Vanadium pentoxide (orthorhombic crystalline form) Vinblastine sulfate Vinclozolin Vinclozolin Vincristine sulfate Vinyl bromide Vinyl chloride 4-Vinylcyclohexene 4-Vinylcyclohexene 4-Vinyl-1-cyclohexene diepoxide (Vinyl cyclohexenedioxide) Vinyl cyclohexene dioxide (4-Vinyl-1cyclohexene diepoxide) Vinyl fluoride
FR AB AB
FR SQE LC AB
Vinyl trichloride (1,1,2-Trichloroethane) cancer
11-Feb-05 1-Jul-90 20-Aug-99 15-May-98 1-Jul-90 1-Oct-88 27-Feb-87 1-May-96 7-Aug-09
Warfarin Wood dust
developmental cancer
2,6-Xylidine (2,6-Dimethylaniline)
cancer
AB
87-62-7
Zalcitabine Zidovudine (AZT)
LC LC
7481-89-2 30516-87-1
7-Aug-09 18-Dec-09
Zileuton
cancer cancer cancer, developmental, female
FR
111406-87-2
22-Dec-00
Zineb Delisted October 29, 1999 [Click here for the basis for delisting]
cancer
AB
12122-67-7
1-Jan-90
- 28 -
Chemical
Type of Toxicity
Listing Mechanism
CAS No.
Date Listed
a
Where a source or product results in exposures by multiple routes, the total exposure must be considered. For example, the MADL for benzene is exceeded when the absorbed dose exceeds 24 µg/day. If only inhalation and oral exposure occurs, the benzene MADL is exceeded when: (oral dose ÷ 24 µg/day) + (inhalation dose ÷ 49 µg/day) > 1.0. b
Level represents absorbed dose (rounded from 6,525 µg/day ). Since 100% of ingested toluene is absorbed, oral dose is equivalent to istered dose. It is assumed that roughly 50% of the dose istered by the inhalation route is absorbed. Therefore the MADL for inhaled toluene is 13,000 µg/day (rounded from 13,050 µg/day ), corresponding to an absorbed dose of 6,525 µg/day.
- 29 -
CITY
vise and republish ive toxicity. For ndpoints shown in been removed. A
s Qualified Code. For those nk to the hemical Abstracts esented as a e chemicals for MADL) for or those NSRLs or to the
NSRL or MADL a (µg/day)
2 90 (inhalation) 10
0.2
0.2 140
0.7 0.00008
- 30 -
NSRL or MADL (µg/day)a 3
0.04
20 0.2 0.03
9
5 0.04
0.7
- 31 -
NSRL or MADL (µg/day)a 100 5 7
20
0.06 (inhalation) 10 (except inhalation) 100 fibers/day (inhalation)
0.8 4.4 0.06 0.4
6
0.033 (oral) 6.4 (oral) 13 (inhalation) - 32 -
NSRL or MADL (µg/day)a 24 (oral) 49 (inhalation)
0.001
0.096 (oral) 0.11 (oral) 1.1
0.06
4 30
0.1 0.1 0.0002
0.3
0.02
5 64
- 33 -
NSRL or MADL (µg/day)a
0.4
4000
0.7
4.1 (oral)
0.05 (inhalation) 5 300
4.1
5
0.7
- 34 -
NSRL or MADL (µg/day)a
0.002
0.5 0.04
8
8 0.37 0.48
150
20 (oral) 40 (inhalation)
0.3 5 40
200 3
- 35 -
NSRL or MADL (µg/day)a
3.3
0.003
0.001 (inhalation) 8.2 (oral) 0.35 (oral) 3 50
200
0.3
- 36 -
NSRL or MADL (µg/day)a
5 3
1
1
100 0.01 40
9
910 - 37 -
NSRL or MADL (µg/day)a 2 (DDT, DDE, DDD in combination) 2 (DDT, DDE, DDD in combination) 2 (DDT, DDE, DDD in combination)
2
30 50 5 0.2
0.2 0.0030 (oral) 0.0054 (oral) 0.0050 (oral)
0.1 - 38 -
NSRL or MADL (µg/day)a 3.1 (oral) 4.3 (inhalation)
20 0.6
100
50 200 (inhalation)
9.7
0.04
310 For intravenous exposure: 4200 (adults) 600 (infant boys, age 29 days- 24 mos.) 210 (neonatal infant boys, age 0-28 days).
- 39 -
NSRL or MADL (µg/day)a For oral exposure: 410 (adults) 58 (infant boys, age 29 days24 mos.) 20 (neonatal infant boys, age 0-28 days). 0.002
0.4 20
2200
0.15 0.19
0.2
2 0.003 0.044 0.059
- 40 -
NSRL or MADL (µg/day)a 0.05 0.001 20 8.7 2200 (oral) 38
2
30
0.09 0.09 0.1 56 (oral) 170 (oral) as 32% pesticidal formulation 200
- 41 -
NSRL or MADL (µg/day)a
9
0.02
54 (inhalation) 41 (oral) 700 (oral and inhalation) 6700 (dermal) 7
0.2 (oral) 3 (inhalation)
10 750 (oral) 960 (inhalation)
- 42 -
NSRL or MADL (µg/day)a 1100 (oral) 1400 (inhalation) 63 (oral) 98 (oral) 0.01
2 20
20
200 40 0.3
- 43 -
NSRL or MADL (µg/day)a 20
0.1 0.5 0.54
0.07
10
0.2 0.08
0.4
- 44 -
NSRL or MADL (µg/day)a 0.2 0.3 0.5 0.6 0.0002 20
120 (oral)
0.04 0.2 0.8
0.5
7.4
- 45 -
NSRL or MADL (µg/day)a
0.09
0.5 15 (oral) 23 (oral) 58 (oral) 41 (oral)
460
0.6
0.46 0.41 0.005
- 46 -
NSRL or MADL (µg/day)a
0.028
810 (inhalation) 160
0.03 0.0084 (oral) 0.5
20 0.8 0.4 0.6
0.058 (oral) 0.090 (inhalation) 0.18 29
- 47 -
NSRL or MADL (µg/day)a
7
0.2 0.08 3200 (inhalation) 17000 (dermal)
2
0.8
0.04 0.00009
0.07
- 48 -
NSRL or MADL (µg/day)a
0.18
0.11
28 5.8 0.4
0.8 0.4
100 70 6
10 - 49 -
NSRL or MADL (µg/day)a
9
0.5 0.4 0.5
39
0.3 0.02 0.04 0.06 0.1 30
80
0.014
0.03 0.1
0.03 0.006 0.006 0.5 - 50 -
NSRL or MADL (µg/day)a 0.07
0.3
40
- 51 -
NSRL or MADL (µg/day)a
300 4 5 0.005 2 0.2 0.3
26 44 5
1 1.4 200
0.02 0.09
1200 200 40 1 720
- 52 -
NSRL or MADL (µg/day)a
0.05 0.06
0.3
0.05
0.7
590
0.06
- 53 -
NSRL or MADL (µg/day)a
3
23 (oral) 58 (oral) as a 40% pesticidal formulation
0.02
0.006
4 4
- 54 -
NSRL or MADL (µg/day)a
0.000005
3
14
0.059 0.1 0.05
600 (oral) 10
7000b 20 4 5 - 55 -
NSRL or MADL (µg/day)a
0.6
50 (oral) 80 (inhalation) 10
24 8.2
0.06 0.3
0.03 0.2 - 56 -
NSRL or MADL (µg/day)a
0.7
3
10
110
- 57 -
NSRL or MADL (µg/day)a
st be considered. day. If only 4 µg/day) +
oluene is the dose s 13,000 µg/day
- 58 -
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