Xampler Hf 6b351a
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GE Healthcare Data File 18-1170-21 AC
Membrane separations
Xampler laboratory membrane cartridges GE Healthcare Xampler™ ultrafiltration and microfiltration cartridges are designed for laboratory scale processing, with typical volumes ranging from a few hundred mls to about 10 liters of solution. Xampler cartridges are offered with nominal flowpath lengths of 30 and 60 cm and membrane areas ranging from 110 to 1,400 cm2 (0.12 to 1.5 ft2). They are directly scalable to GE Healthcare 30- and 60-cm pilot and process scale cartridges. Xampler cartridges have fully self-contained housings and are well-suited for use with GE Healthcare’s QuixStand™ benchtop system. When operated in a vertical orientation complete process fluid drainage and maximum product recovery is achieved. Xampler hollow fiber cartridges are offered with mini Tri-Clamp® end fittings for quick and easy sanitary connection to your laboratory equipment. These cartridges are identified with an “M” in the suffix of the model number. A select portion of the Xampler line is also offered with barbed end fittings for simple flexible tubing connection. Schematic diagrams showing the alternative cartridge sizes and end fittings are provided in Figure 4. All GE Healthcare Xampler microfiltration cartridges are autoclavable. Moreover, all Xampler ultrafiltration cartridges are autoclavable with the exception of 1,000 Dalton nominal molecular weight cutoff (NMWC) membrane units. An “A” as the model number suffix signifies that the particular cartridge may be autoclaved.
Figure 1. Xampler hollow fiber cartridges — Xampler cartridges are available in two housing diameters and two lengths, and are designed for use with QuixStand benchtop systems
Xampler cartridge features and benefits Versatile • Nominal flowpath lengths of 30 and 60 cm facilitate optimization of process conditions and assist future scale-up • Membrane areas from 110 to 1,400 cm2 (0.12 to 1.5 ft2) suit specific processing needs • UF pore sizes range from 1 kD to 750 kD NMWC • MF pore sizes range from 0.1 to 0.65 micron
Designed for the laboratory • Low flow rate requirements allow use of smaller pumps • Polysulfone membrane minimizes non-specific protein binding and provides high product recovery • Autoclavable (with the exception of 1,000 NMWC) devices address the need for small-volume sanitary processing
Easy to use • Self-contained housings with translucent polysulfone shells allow ease of installation and provide a visual observation of the membrane separation process • Offered with Tri-Clamp end fittings for quick and easy aseptic connection
Typical applications • Clarification of lysates and cell cultures • Concentration, diafiltration, and purification of monoclonal antibodies, plasmids, proteins, viruses, vaccines, colloids, and plasma
GE Healthcare QuixStand benchtop system The QuixStand benchtop system is a compact, easy to use laboratory-scale separations system that uses Xampler cartridges for quick and efficient concentration and diafiltration of a wide range of biological solutions. The QuixStand system is capable of rapidly processing solution volumes up to 10 liters. QuixStand systems can be purchased with or without pumps, and are available in non-sanitary, sanitary, and autoclavable versions.
• Manufacturing material for early stage clinical trials • Scale-up/scale-down studies
GE Healthcare hollow fiber membrane The outstanding performance of GE Healthcare hollow fiber products is based on a proprietary manufacturing process that yields membrane with a structure free of macrovoids and pinhole defects associated with conventional hollow fiber membranes. Separation processes which incorporate a defect-free membrane can use broader operating parameters without compromising membrane performance or integrity.
Figure 3. Sanitary QuixStand benchtop system with peristaltic pump and Xampler size 4M hollow fiber cartridge
Figure 2. Conventional hollow fiber ultrafiltration membrane (left) and GE Healthcare ultrafiltration membrane (right)
2
Data File 18-1170-21 AC
Xampler cartridges Physical specifications
Cartridge diameter 3M, 3X2M 4, 4M, 4X2M
0.9 cm (0.375 in) 1.9 cm (0.75 in)
Cartridge length 3M 3X2M 4 4M 4X2M
31.7 cm (12.5 in) 63.5 cm (25 in) 36.2 cm (14.25 in) 34.5 cm (13.6 cm) 66 cm (26 in)
Path length 3M, 4, 4M 3X2M, 4X2M
30 cm (12 in) 60 cm (24 in)
Feed/retentate connections 3M, 3X2M, 4M, 4X2M 4
0.5-in Tri-clamp 0.375-in tubing barb
Permeate connections 3M, 3X2M 4, 4M, 4X2M
0.25-in tubing nipple 0.375-in tubing nipple
Materials of construction Hollow fibers Housing components Potting net (4, 4M, 4X2M) Fitting caps
Polysulfone Polysulfone Epoxy Polypropylene Vinyl
Biological safety USP XXVII Class VI
Compliant
Operating specifications
Ultrafiltration
Microfiltration
Temperature range
Up to 80°C
0.1 and 0.2 μm: up to 80°C 0.45 and 0.65 μm: up to 50°C
Maximum feed pressure
<10°C: 5.2 barg (75 psig) 10°C-25°C: 4.5 barg (65 psig) 25°C-80°C: 3.4 barg (50 psig)
At 25°C: 0.1 μm: 2.1 barg (30 psig) 0.2 μm: 1.7 barg (25 psig) 0.45 μm: 1 barg (15 psig) 0.65 μm: 1 barg (15 psig)
Maximum transmembrane pressure
3 kD – 30 kD: <10°C: 4.1 barg (60 psig) 10°C-25°C: 3.4 barg (50 psig) 25°C-50°C: 3.1 barg (45 psig) 50°C-80°C: 2.4 barg (35 psig)
At 25°C: 0.1 μm: 1.4 barg (20 psig) 0.2 μm: 1 barg (15 psig) 0.45 μm: 0.7 barg (10 psig) 0.65 μm: 0.7 barg (10 psig)
100 kD – 750 kD: <10°C: 3.4 barg (50 psig) 10°C-25°C: 3.1 barg (45 psig) 25°C-50°C: 2.4 barg (35 psig) 50°C-80°C: 1.7 barg (25 psig) Chlorine Sanitization Cleaning (30 minutes, 50°C) Continuous @ 20°C
5 to 50 ppm 100 ppm 100 ppm
5 to 50 ppm 300 ppm 100 ppm
pH range
2-13
2-13
Data File 18-1170-21 AC
3
Surface area Housing identifier
Nominal lumen ID (mm)
Membrane area (cm2) (ft2)
3M
0.5 0.75 1
140 120 110
0.15 0.13 0.12
3X2M
0.5 1
290 230
0.31 0.24
4, 4M
0.5 0.75 1
650 460 420
0.70 0.50 0.45
4X2M
0.5 0.75 1 1.75
1,400 950 850 650
1.5 1.02 0.91 0.70
Nominal feed stream flow rates (ml/min) for Xampler 3M and 3X2M hollow fiber cartridges Nominal lumen ID (mm)
Shear rate* ~2,000 sec-1
Shear rate ~4,000 sec-1
Shear rate ~8,000 sec-1
Shear rate ~16,000 sec-1
0.5 0.75 1
60 100 150
120 200 300
250 400 600
500 800 1,200
* Based on a fluid viscosity of 1
Nominal feed stream flow rates (ml/min) for Xampler 4, 4M, and 4X2M hollow fiber cartridges Nominal lumen ID (mm)
Shear rate* ~2,000 sec-1
Shear rate ~4,000 sec-1
Shear rate ~8,000 sec-1
0.5 0.75 1 1.75
300 400 600 1,500
600 800 1,200 3,000
1,200 1,500 2,500 6,000
4
Data File 18-1170-21 AC
Shear rate ~16,000 sec-1
2,400 3,000 5,000 12,000
Housing 3M
Housing 4
Housing 4M
Length = 31.7 cm (12.5 in) Diameter = 0.9 cm (0.375 in) Permeate ports = 0.25-in tubing nipple Feed/retentate ports = 0.5-in Tri-Clamp
Length = 36.2 cm (14.25 in) Diameter = 1.9 cm (0.75 in) Permeate ports = 0.375-in tubing nipple Feed/retentate ports = 0.375-in tubing barb
Length = 34.5 cm (13.6 in) Diameter = 1.9 cm (0.75 in) Permeate ports = 0.375-in tubing nipple Feed/retentate ports = 0.5-in Tri-Clamp
Housing 3X2M
Housing 4X2M
Length = 63.5 cm (25 in) Diameter = 0.9 cm (0.375 in ) Permeate ports = 0.25-in tubing nipples Feed/retentate ports = 0.5-in Tri-Clamp
Length = 66 cm (26 in) Diameter = 1.9 cm (0.75 in) Permeate ports = 0.375-in tubing nipples Feed/retentate ports = 0.5-in Tri-Clamp
Figure 4. Xampler laboratory cartridges (drawings not to scale)
Data File 18-1170-21 AC
5
Ordering information Xampler ultrafiltration cartridges Code number
Model number
Pore size (NMWC)
Fiber ID (mm)
Membrane area (cm2) (ft2)
Nominal flowpath length (cm)
56-4101-20 56-4101-22 56-4101-23 56-4101-24 56-4101-25 56-4101-27 56-4101-28 56-4101-29 56-4101-30 56-4101-31 56-4101-32 56-4101-33 56-4101-34 56-4101-35 56-4101-36 56-4101-37 56-4101-38 56-4101-39 56-4101-45 56-4101-46 56-4101-47 56-4101-48 56-4101-49 56-4101-50 56-4101-51 56-4101-52 56-4101-53 56-4101-54 56-4101-55 56-4101-84 56-4101-87 56-4101-88 56-4101-89 56-4101-90 56-4101-91 56-4101-92 56-4101-93 56-4101-94 56-4101-95 56-4101-96 56-4101-97 56-4101-98 56-4101-99 56-4102-00 56-4102-01 56-4102-02 56-4102-03 56-4101-59 56-4101-61 56-4101-62 56-4101-63 56-4101-64 56-4101-66 56-4101-67 56-4101-68 56-4101-69 56-4101-70 56-4101-71 56-4101-72 56-4101-73 56-4101-74 56-4101-75 56-4101-76 56-4101-77 56-4101-78
UFP-1-C-3M UFP-3-C-3MA UFP-3-E-3MA UFP-5-C-3MA UFP-5-E-3MA UFP-10-C-3MA UFP-10-E-3MA UFP-30-C-3MA UFP-30-E-3MA UFP-50-C-3MA UFP-50-E-3MA UFP-100-C-3MA UFP-100-E-3MA UFP-300-C-3MA UFP-300-E-3MA UFP-500-C-3MA UFP-500-E-3MA UFP-750-E-3MA UFP-3-C-3X2MA UFP-10-C-3X2MA UFP-30-C-3X2MA UFP-50-C-3X2MA UFP-100-C-3X2MA UFP-100-E-3X2MA UFP-300-C-3X2MA UFP-300-E-3X2MA UFP-500-C-3X2MA UFP-500-E-3X2MA UFP-750-E-3X2MA UFP-1-C-4 UFP-3-C-4A UFP-3-E-4A UFP-5-C-4A UFP-5-E-4A UFP-10-C-4A UFP-10-E-4A UFP-30-C-4A UFP-30-E-4A UFP-50-C-4A UFP-50-E-4A UFP-100-C-4A UFP-100-E-4A UFP-300-C-4A UFP-300-E-4A UFP-500-C-4A UFP-500-E-4A UFP-750-E-4A UFP-1-C-4M UFP-3-C-4MA UFP-3-E-4MA UFP-5-C-4MA UFP-5-E-4MA UFP-10-C-4MA UFP-10-E-4MA UFP-30-C-4MA UFP-30-E-4MA UFP-50-C-4MA UFP-50-E-4MA UFP-100-C-4MA UFP-100-E-4MA UFP-300-C-4MA UFP-300-E-4MA UFP-500-C-4MA UFP-500-E-4MA UFP-750-E-4MA
1,000 3,000 3,000 5,000 5,000 10,000 10,000 30,000 30,000 50,000 50,000 100,000 100,000 300,000 300,000 500,000 500,000 750,000 3,000 10,000 30,000 50,000 100,000 100,000 300,000 300,000 500,000 500,000 750,000 1,000 3,000 3,000 5,000 5,000 10,000 10,000 30,000 30,000 50,000 50,000 100,000 100,000 300,000 300,000 500,000 500,000 750,000 1,000 3,000 3,000 5,000 5,000 10,000 10,000 30,000 30,000 50,000 50,000 100,000 100,000 300,000 300,000 500,000 500,000 750,000
0.5 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 1 0.5 0.5 0.5 0.5 0.5 1 0.5 1 0.5 1 1 0.5 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 1 0.5 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 1
140 140 110 140 110 140 110 140 110 140 110 140 110 140 110 140 110 110 290 290 290 290 290 230 290 230 290 230 230 650 650 420 650 420 650 420 650 420 650 420 650 420 650 420 650 420 420 650 650 420 650 420 650 420 650 420 650 420 650 420 650 420 650 420 420
30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 60 60 60 60 60 60 60 60 60 60 60 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30
0.15 0.15 0.12 0.15 0.12 0.15 0.12 0.15 0.12 0.15 0.12 0.15 0.12 0.15 0.12 0.15 0.12 0.12 0.31 0.31 0.31 0.31 0.31 0.24 0.31 0.24 0.31 0.24 0.24 0.70 0.70 0.45 0.70 0.45 0.70 0.45 0.70 0.45 0.70 0.45 0.70 0.45 0.70 0.45 0.70 0.45 0.45 0.70 0.70 0.45 0.70 0.45 0.70 0.45 0.70 0.45 0.70 0.45 0.70 0.45 0.70 0.45 0.70 0.45 0.45
(continued) 6
Data File 18-1170-21 AC
Xampler ultrafiltration cartridges (continued) Code number
Model number
Pore size (NMWC)
Fiber ID (mm)
Membrane area (cm2) (ft2)
Nominal flowpath length (cm)
11-0004-97 56-4102-09 56-4102-10 56-4110-17 56-4102-11 56-4110-04 56-4102-12 56-4110-18 56-4102-13 56-4110-19 56-4102-14 56-4102-15 56-4102-16 56-4102-17 56-4102-18 56-4102-19 56-4102-20
UFP-1-C-4X2M UFP-3-C-4X2MA UFP-5-C-4X2MA UFP-5-E-4X2MA UFP-10-C-4X2MA UFP-10-E-4X2MA UFP-30-C-4X2MA UFP-30-E-4X2MA UFP-50-C-4X2MA UFP-50-E-4X2MA UFP-100-C-4X2MA UFP-100-E-4X2MA UFP-300-C-4X2MA UFP-300-E-4X2MA UFP-500-C-4X2MA UFP-500-E-4X2MA UFP-750-E-4X2MA
1,000 3,000 5,000 5,000 10,000 10,000 30,000 30,000 50,000 50,000 100,000 100,000 300,000 300,000 500,000 500,000 750,000
0.5 0.5 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 1
1,400 1,400 1,400 850 1,400 850 1,400 850 1,400 850 1,400 850 1,400 850 1,400 850 850
60 60 60 60 60 60 60 60 60 60 60 60 60 60 60 60 60
1.5 1.5 1.5 0.9 1.5 0.9 1.5 0.9 1.5 0.9 1.5 0.9 1.5 0.9 1.5 0.9 0.9
Xampler microfiltration cartridges Code number
Model number
Pore size (μm)
Fiber ID (mm)
Membrane area (cm2) (ft2)
Nominal flowpath length (cm)
56-4101-40 56-4101-41 56-4101-42 56-4101-43 56-4101-44 56-4101-56 56-4101-57 56-4101-58 56-4102-04 56-4102-05 56-4102-06 56-4102-07 56-4102-08 56-4101-79 56-4101-80 56-4101-81 56-4101-82 56-4101-83 56-4102-21 56-4102-22 56-4102-23 11-0005-08 56-4102-24 56-4102-25
CFP-1-D-3MA CFP-1-E-3MA CFP-2-E-3MA CFP-4-E-3MA CFP-6-D-3MA CFP-1-E-3X2MA CFP-2-E-3X2MA CFP-4-E-3X2MA CFP-1-D-4A CFP-1-E-4A CFP-2-E-4A CFP-4-E-4A CFP-6-D-4A CFP-1-D-4MA CFP-1-E-4MA CFP-2-E-4MA CFP-4-E-4MA CFP-6-D-4MA CFP-1-D-4X2MA CFP-1-E-4X2MA CFP-2-E-4X2MA CFP-2-G-4X2MA CFP-4-E-4X2MA CFP-6-D-4X2MA
0.1 0.1 0.2 0.45 0.65 0.1 0.2 0.45 0.1 0.1 0.2 0.45 0.65 0.1 0.1 0.2 0.45 0.65 0.1 0.1 0.2 0.2 0.45 0.65
0.75 1 1 1 0.75 1 1 1 0.75 1 1 1 0.75 0.75 1 1 1 0.75 0.75 1 1 1.75 1 0.75
120 110 110 110 120 230 230 230 460 420 420 420 460 460 420 420 420 460 950 850 850 650 850 950
30 30 30 30 30 60 60 60 30 30 30 30 30 30 30 30 30 30 60 60 60 60 60 60
0.13 0.12 0.12 0.12 0.13 0.24 0.24 0.24 0.5 0.45 0.45 0.45 0.5 0.5 0.45 0.45 0.45 0.50 1.02 0.9 0.9 0.7 0.9 1.02
Data File 18-1170-21 AC
7
www.gehealthcare.com
QuixStand and Xampler are trademarks of General Electric Company. GE tagline and GE Monogram are trademarks of General Electric Company.
Global Headquarters GE Healthcare Little Chalfont Buckinghamshire, U.K. HP7 9NA
Tri-Clamp is a ed trademark of Tri-Clover, Alfa Laval. All goods and services are sold subject to the and conditions of sale of the company within GE Healthcare which supplies them. GE Healthcare reserves the right, subject to any regulatory and contractual approval, if required, to make changes in specifications and features shown herein, or discontinue the product described at any time without notice or obligation. © 2005 General Electric Company–All rights reserved. Amersham Biosciences AB, a General Electric Company going to market as GE Healthcare. GE Healthcare Amersham Biosciences AB Björkgatan 30, 751 84 Uppsala, Sweden GE Healthcare Amersham Biosciences Europe GmbH Munzinger Strasse 9, D-79111 Freiburg, GE Healthcare Amersham Biosciences UK Ltd Amersham Place, Little Chalfont, Buckinghamshire, HP7 9NA, UK GE Healthcare Amersham Biosciences Corp 800 Centennial Avenue, P.O. Box 1327, Piscataway, NJ 08855-1327, USA GE Healthcare Amersham Biosciences KK Sanken Bldg. 3-25-1, Hyakunincho, Shinjuku-ku, Tokyo 169-0073, Japan GE Healthcare Amersham Biosciences Ltd 13/F, Tower 1, Ever Gain Plaza, 88 Container Port Road Kwai Chung, New Territories, HONG KONG
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18-1170-21 AC
Membrane separations
Xampler laboratory membrane cartridges GE Healthcare Xampler™ ultrafiltration and microfiltration cartridges are designed for laboratory scale processing, with typical volumes ranging from a few hundred mls to about 10 liters of solution. Xampler cartridges are offered with nominal flowpath lengths of 30 and 60 cm and membrane areas ranging from 110 to 1,400 cm2 (0.12 to 1.5 ft2). They are directly scalable to GE Healthcare 30- and 60-cm pilot and process scale cartridges. Xampler cartridges have fully self-contained housings and are well-suited for use with GE Healthcare’s QuixStand™ benchtop system. When operated in a vertical orientation complete process fluid drainage and maximum product recovery is achieved. Xampler hollow fiber cartridges are offered with mini Tri-Clamp® end fittings for quick and easy sanitary connection to your laboratory equipment. These cartridges are identified with an “M” in the suffix of the model number. A select portion of the Xampler line is also offered with barbed end fittings for simple flexible tubing connection. Schematic diagrams showing the alternative cartridge sizes and end fittings are provided in Figure 4. All GE Healthcare Xampler microfiltration cartridges are autoclavable. Moreover, all Xampler ultrafiltration cartridges are autoclavable with the exception of 1,000 Dalton nominal molecular weight cutoff (NMWC) membrane units. An “A” as the model number suffix signifies that the particular cartridge may be autoclaved.
Figure 1. Xampler hollow fiber cartridges — Xampler cartridges are available in two housing diameters and two lengths, and are designed for use with QuixStand benchtop systems
Xampler cartridge features and benefits Versatile • Nominal flowpath lengths of 30 and 60 cm facilitate optimization of process conditions and assist future scale-up • Membrane areas from 110 to 1,400 cm2 (0.12 to 1.5 ft2) suit specific processing needs • UF pore sizes range from 1 kD to 750 kD NMWC • MF pore sizes range from 0.1 to 0.65 micron
Designed for the laboratory • Low flow rate requirements allow use of smaller pumps • Polysulfone membrane minimizes non-specific protein binding and provides high product recovery • Autoclavable (with the exception of 1,000 NMWC) devices address the need for small-volume sanitary processing
Easy to use • Self-contained housings with translucent polysulfone shells allow ease of installation and provide a visual observation of the membrane separation process • Offered with Tri-Clamp end fittings for quick and easy aseptic connection
Typical applications • Clarification of lysates and cell cultures • Concentration, diafiltration, and purification of monoclonal antibodies, plasmids, proteins, viruses, vaccines, colloids, and plasma
GE Healthcare QuixStand benchtop system The QuixStand benchtop system is a compact, easy to use laboratory-scale separations system that uses Xampler cartridges for quick and efficient concentration and diafiltration of a wide range of biological solutions. The QuixStand system is capable of rapidly processing solution volumes up to 10 liters. QuixStand systems can be purchased with or without pumps, and are available in non-sanitary, sanitary, and autoclavable versions.
• Manufacturing material for early stage clinical trials • Scale-up/scale-down studies
GE Healthcare hollow fiber membrane The outstanding performance of GE Healthcare hollow fiber products is based on a proprietary manufacturing process that yields membrane with a structure free of macrovoids and pinhole defects associated with conventional hollow fiber membranes. Separation processes which incorporate a defect-free membrane can use broader operating parameters without compromising membrane performance or integrity.
Figure 3. Sanitary QuixStand benchtop system with peristaltic pump and Xampler size 4M hollow fiber cartridge
Figure 2. Conventional hollow fiber ultrafiltration membrane (left) and GE Healthcare ultrafiltration membrane (right)
2
Data File 18-1170-21 AC
Xampler cartridges Physical specifications
Cartridge diameter 3M, 3X2M 4, 4M, 4X2M
0.9 cm (0.375 in) 1.9 cm (0.75 in)
Cartridge length 3M 3X2M 4 4M 4X2M
31.7 cm (12.5 in) 63.5 cm (25 in) 36.2 cm (14.25 in) 34.5 cm (13.6 cm) 66 cm (26 in)
Path length 3M, 4, 4M 3X2M, 4X2M
30 cm (12 in) 60 cm (24 in)
Feed/retentate connections 3M, 3X2M, 4M, 4X2M 4
0.5-in Tri-clamp 0.375-in tubing barb
Permeate connections 3M, 3X2M 4, 4M, 4X2M
0.25-in tubing nipple 0.375-in tubing nipple
Materials of construction Hollow fibers Housing components Potting net (4, 4M, 4X2M) Fitting caps
Polysulfone Polysulfone Epoxy Polypropylene Vinyl
Biological safety USP XXVII Class VI
Compliant
Operating specifications
Ultrafiltration
Microfiltration
Temperature range
Up to 80°C
0.1 and 0.2 μm: up to 80°C 0.45 and 0.65 μm: up to 50°C
Maximum feed pressure
<10°C: 5.2 barg (75 psig) 10°C-25°C: 4.5 barg (65 psig) 25°C-80°C: 3.4 barg (50 psig)
At 25°C: 0.1 μm: 2.1 barg (30 psig) 0.2 μm: 1.7 barg (25 psig) 0.45 μm: 1 barg (15 psig) 0.65 μm: 1 barg (15 psig)
Maximum transmembrane pressure
3 kD – 30 kD: <10°C: 4.1 barg (60 psig) 10°C-25°C: 3.4 barg (50 psig) 25°C-50°C: 3.1 barg (45 psig) 50°C-80°C: 2.4 barg (35 psig)
At 25°C: 0.1 μm: 1.4 barg (20 psig) 0.2 μm: 1 barg (15 psig) 0.45 μm: 0.7 barg (10 psig) 0.65 μm: 0.7 barg (10 psig)
100 kD – 750 kD: <10°C: 3.4 barg (50 psig) 10°C-25°C: 3.1 barg (45 psig) 25°C-50°C: 2.4 barg (35 psig) 50°C-80°C: 1.7 barg (25 psig) Chlorine Sanitization Cleaning (30 minutes, 50°C) Continuous @ 20°C
5 to 50 ppm 100 ppm 100 ppm
5 to 50 ppm 300 ppm 100 ppm
pH range
2-13
2-13
Data File 18-1170-21 AC
3
Surface area Housing identifier
Nominal lumen ID (mm)
Membrane area (cm2) (ft2)
3M
0.5 0.75 1
140 120 110
0.15 0.13 0.12
3X2M
0.5 1
290 230
0.31 0.24
4, 4M
0.5 0.75 1
650 460 420
0.70 0.50 0.45
4X2M
0.5 0.75 1 1.75
1,400 950 850 650
1.5 1.02 0.91 0.70
Nominal feed stream flow rates (ml/min) for Xampler 3M and 3X2M hollow fiber cartridges Nominal lumen ID (mm)
Shear rate* ~2,000 sec-1
Shear rate ~4,000 sec-1
Shear rate ~8,000 sec-1
Shear rate ~16,000 sec-1
0.5 0.75 1
60 100 150
120 200 300
250 400 600
500 800 1,200
* Based on a fluid viscosity of 1
Nominal feed stream flow rates (ml/min) for Xampler 4, 4M, and 4X2M hollow fiber cartridges Nominal lumen ID (mm)
Shear rate* ~2,000 sec-1
Shear rate ~4,000 sec-1
Shear rate ~8,000 sec-1
0.5 0.75 1 1.75
300 400 600 1,500
600 800 1,200 3,000
1,200 1,500 2,500 6,000
4
Data File 18-1170-21 AC
Shear rate ~16,000 sec-1
2,400 3,000 5,000 12,000
Housing 3M
Housing 4
Housing 4M
Length = 31.7 cm (12.5 in) Diameter = 0.9 cm (0.375 in) Permeate ports = 0.25-in tubing nipple Feed/retentate ports = 0.5-in Tri-Clamp
Length = 36.2 cm (14.25 in) Diameter = 1.9 cm (0.75 in) Permeate ports = 0.375-in tubing nipple Feed/retentate ports = 0.375-in tubing barb
Length = 34.5 cm (13.6 in) Diameter = 1.9 cm (0.75 in) Permeate ports = 0.375-in tubing nipple Feed/retentate ports = 0.5-in Tri-Clamp
Housing 3X2M
Housing 4X2M
Length = 63.5 cm (25 in) Diameter = 0.9 cm (0.375 in ) Permeate ports = 0.25-in tubing nipples Feed/retentate ports = 0.5-in Tri-Clamp
Length = 66 cm (26 in) Diameter = 1.9 cm (0.75 in) Permeate ports = 0.375-in tubing nipples Feed/retentate ports = 0.5-in Tri-Clamp
Figure 4. Xampler laboratory cartridges (drawings not to scale)
Data File 18-1170-21 AC
5
Ordering information Xampler ultrafiltration cartridges Code number
Model number
Pore size (NMWC)
Fiber ID (mm)
Membrane area (cm2) (ft2)
Nominal flowpath length (cm)
56-4101-20 56-4101-22 56-4101-23 56-4101-24 56-4101-25 56-4101-27 56-4101-28 56-4101-29 56-4101-30 56-4101-31 56-4101-32 56-4101-33 56-4101-34 56-4101-35 56-4101-36 56-4101-37 56-4101-38 56-4101-39 56-4101-45 56-4101-46 56-4101-47 56-4101-48 56-4101-49 56-4101-50 56-4101-51 56-4101-52 56-4101-53 56-4101-54 56-4101-55 56-4101-84 56-4101-87 56-4101-88 56-4101-89 56-4101-90 56-4101-91 56-4101-92 56-4101-93 56-4101-94 56-4101-95 56-4101-96 56-4101-97 56-4101-98 56-4101-99 56-4102-00 56-4102-01 56-4102-02 56-4102-03 56-4101-59 56-4101-61 56-4101-62 56-4101-63 56-4101-64 56-4101-66 56-4101-67 56-4101-68 56-4101-69 56-4101-70 56-4101-71 56-4101-72 56-4101-73 56-4101-74 56-4101-75 56-4101-76 56-4101-77 56-4101-78
UFP-1-C-3M UFP-3-C-3MA UFP-3-E-3MA UFP-5-C-3MA UFP-5-E-3MA UFP-10-C-3MA UFP-10-E-3MA UFP-30-C-3MA UFP-30-E-3MA UFP-50-C-3MA UFP-50-E-3MA UFP-100-C-3MA UFP-100-E-3MA UFP-300-C-3MA UFP-300-E-3MA UFP-500-C-3MA UFP-500-E-3MA UFP-750-E-3MA UFP-3-C-3X2MA UFP-10-C-3X2MA UFP-30-C-3X2MA UFP-50-C-3X2MA UFP-100-C-3X2MA UFP-100-E-3X2MA UFP-300-C-3X2MA UFP-300-E-3X2MA UFP-500-C-3X2MA UFP-500-E-3X2MA UFP-750-E-3X2MA UFP-1-C-4 UFP-3-C-4A UFP-3-E-4A UFP-5-C-4A UFP-5-E-4A UFP-10-C-4A UFP-10-E-4A UFP-30-C-4A UFP-30-E-4A UFP-50-C-4A UFP-50-E-4A UFP-100-C-4A UFP-100-E-4A UFP-300-C-4A UFP-300-E-4A UFP-500-C-4A UFP-500-E-4A UFP-750-E-4A UFP-1-C-4M UFP-3-C-4MA UFP-3-E-4MA UFP-5-C-4MA UFP-5-E-4MA UFP-10-C-4MA UFP-10-E-4MA UFP-30-C-4MA UFP-30-E-4MA UFP-50-C-4MA UFP-50-E-4MA UFP-100-C-4MA UFP-100-E-4MA UFP-300-C-4MA UFP-300-E-4MA UFP-500-C-4MA UFP-500-E-4MA UFP-750-E-4MA
1,000 3,000 3,000 5,000 5,000 10,000 10,000 30,000 30,000 50,000 50,000 100,000 100,000 300,000 300,000 500,000 500,000 750,000 3,000 10,000 30,000 50,000 100,000 100,000 300,000 300,000 500,000 500,000 750,000 1,000 3,000 3,000 5,000 5,000 10,000 10,000 30,000 30,000 50,000 50,000 100,000 100,000 300,000 300,000 500,000 500,000 750,000 1,000 3,000 3,000 5,000 5,000 10,000 10,000 30,000 30,000 50,000 50,000 100,000 100,000 300,000 300,000 500,000 500,000 750,000
0.5 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 1 0.5 0.5 0.5 0.5 0.5 1 0.5 1 0.5 1 1 0.5 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 1 0.5 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 1
140 140 110 140 110 140 110 140 110 140 110 140 110 140 110 140 110 110 290 290 290 290 290 230 290 230 290 230 230 650 650 420 650 420 650 420 650 420 650 420 650 420 650 420 650 420 420 650 650 420 650 420 650 420 650 420 650 420 650 420 650 420 650 420 420
30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 60 60 60 60 60 60 60 60 60 60 60 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30
0.15 0.15 0.12 0.15 0.12 0.15 0.12 0.15 0.12 0.15 0.12 0.15 0.12 0.15 0.12 0.15 0.12 0.12 0.31 0.31 0.31 0.31 0.31 0.24 0.31 0.24 0.31 0.24 0.24 0.70 0.70 0.45 0.70 0.45 0.70 0.45 0.70 0.45 0.70 0.45 0.70 0.45 0.70 0.45 0.70 0.45 0.45 0.70 0.70 0.45 0.70 0.45 0.70 0.45 0.70 0.45 0.70 0.45 0.70 0.45 0.70 0.45 0.70 0.45 0.45
(continued) 6
Data File 18-1170-21 AC
Xampler ultrafiltration cartridges (continued) Code number
Model number
Pore size (NMWC)
Fiber ID (mm)
Membrane area (cm2) (ft2)
Nominal flowpath length (cm)
11-0004-97 56-4102-09 56-4102-10 56-4110-17 56-4102-11 56-4110-04 56-4102-12 56-4110-18 56-4102-13 56-4110-19 56-4102-14 56-4102-15 56-4102-16 56-4102-17 56-4102-18 56-4102-19 56-4102-20
UFP-1-C-4X2M UFP-3-C-4X2MA UFP-5-C-4X2MA UFP-5-E-4X2MA UFP-10-C-4X2MA UFP-10-E-4X2MA UFP-30-C-4X2MA UFP-30-E-4X2MA UFP-50-C-4X2MA UFP-50-E-4X2MA UFP-100-C-4X2MA UFP-100-E-4X2MA UFP-300-C-4X2MA UFP-300-E-4X2MA UFP-500-C-4X2MA UFP-500-E-4X2MA UFP-750-E-4X2MA
1,000 3,000 5,000 5,000 10,000 10,000 30,000 30,000 50,000 50,000 100,000 100,000 300,000 300,000 500,000 500,000 750,000
0.5 0.5 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 0.5 1 1
1,400 1,400 1,400 850 1,400 850 1,400 850 1,400 850 1,400 850 1,400 850 1,400 850 850
60 60 60 60 60 60 60 60 60 60 60 60 60 60 60 60 60
1.5 1.5 1.5 0.9 1.5 0.9 1.5 0.9 1.5 0.9 1.5 0.9 1.5 0.9 1.5 0.9 0.9
Xampler microfiltration cartridges Code number
Model number
Pore size (μm)
Fiber ID (mm)
Membrane area (cm2) (ft2)
Nominal flowpath length (cm)
56-4101-40 56-4101-41 56-4101-42 56-4101-43 56-4101-44 56-4101-56 56-4101-57 56-4101-58 56-4102-04 56-4102-05 56-4102-06 56-4102-07 56-4102-08 56-4101-79 56-4101-80 56-4101-81 56-4101-82 56-4101-83 56-4102-21 56-4102-22 56-4102-23 11-0005-08 56-4102-24 56-4102-25
CFP-1-D-3MA CFP-1-E-3MA CFP-2-E-3MA CFP-4-E-3MA CFP-6-D-3MA CFP-1-E-3X2MA CFP-2-E-3X2MA CFP-4-E-3X2MA CFP-1-D-4A CFP-1-E-4A CFP-2-E-4A CFP-4-E-4A CFP-6-D-4A CFP-1-D-4MA CFP-1-E-4MA CFP-2-E-4MA CFP-4-E-4MA CFP-6-D-4MA CFP-1-D-4X2MA CFP-1-E-4X2MA CFP-2-E-4X2MA CFP-2-G-4X2MA CFP-4-E-4X2MA CFP-6-D-4X2MA
0.1 0.1 0.2 0.45 0.65 0.1 0.2 0.45 0.1 0.1 0.2 0.45 0.65 0.1 0.1 0.2 0.45 0.65 0.1 0.1 0.2 0.2 0.45 0.65
0.75 1 1 1 0.75 1 1 1 0.75 1 1 1 0.75 0.75 1 1 1 0.75 0.75 1 1 1.75 1 0.75
120 110 110 110 120 230 230 230 460 420 420 420 460 460 420 420 420 460 950 850 850 650 850 950
30 30 30 30 30 60 60 60 30 30 30 30 30 30 30 30 30 30 60 60 60 60 60 60
0.13 0.12 0.12 0.12 0.13 0.24 0.24 0.24 0.5 0.45 0.45 0.45 0.5 0.5 0.45 0.45 0.45 0.50 1.02 0.9 0.9 0.7 0.9 1.02
Data File 18-1170-21 AC
7
www.gehealthcare.com
QuixStand and Xampler are trademarks of General Electric Company. GE tagline and GE Monogram are trademarks of General Electric Company.
Global Headquarters GE Healthcare Little Chalfont Buckinghamshire, U.K. HP7 9NA
Tri-Clamp is a ed trademark of Tri-Clover, Alfa Laval. All goods and services are sold subject to the and conditions of sale of the company within GE Healthcare which supplies them. GE Healthcare reserves the right, subject to any regulatory and contractual approval, if required, to make changes in specifications and features shown herein, or discontinue the product described at any time without notice or obligation. © 2005 General Electric Company–All rights reserved. Amersham Biosciences AB, a General Electric Company going to market as GE Healthcare. GE Healthcare Amersham Biosciences AB Björkgatan 30, 751 84 Uppsala, Sweden GE Healthcare Amersham Biosciences Europe GmbH Munzinger Strasse 9, D-79111 Freiburg, GE Healthcare Amersham Biosciences UK Ltd Amersham Place, Little Chalfont, Buckinghamshire, HP7 9NA, UK GE Healthcare Amersham Biosciences Corp 800 Centennial Avenue, P.O. Box 1327, Piscataway, NJ 08855-1327, USA GE Healthcare Amersham Biosciences KK Sanken Bldg. 3-25-1, Hyakunincho, Shinjuku-ku, Tokyo 169-0073, Japan GE Healthcare Amersham Biosciences Ltd 13/F, Tower 1, Ever Gain Plaza, 88 Container Port Road Kwai Chung, New Territories, HONG KONG
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18-1170-21 AC
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