Alex 1b3b4n

Ingredients in Alex • • • • •

Dextromethorphan Hydrobromide Guaiphenesin Phenylephrine Hydrochloride Chlorpheniramine maleate Paracetamol

Dextromethorphan Hydrobromide (DMR) • Non - narcotic cough suppressant (anti tussive). • Acts centrally on cough centre, (Medulla) and elevates the threshold for coughing. • Equipotent to codeine in depressing cough reflex.

• Average dose is 10 to 30 mg 3 to 6 times daily. • Exerts effect within 15-30 minutes after oral istration. • Duration of action is 5-6 hours. Sales Training

Favorable Features of Dextromethorphan Hydrobromide • Equipotent antitussive to Codeine, Pholcodiene which are narcotic. • No addictive properties. • Does not cause CNS depression nor it affects respiratory rate. • Does not cause drowsiness, constipation unlike codeine. • Is safe & effective.

Guaiphenesin • Most commonly used expectorant. • Increases the output of respiratory tract fluids, this helps to liquefy the thick mucus. • Though not a cough suppressant reduces the intensity and frequency of dry or productive cough.

Phenylephrine Hydrochloride • It is oral nasal decongestant.

• Phenylephrine effects its vasoconstrictor activity by releasing noradrenaline from sympathetic nerve endings and from direct stimulation of (alpha)-adreno receptors in blood vessels. • Half-life is approximately 2-3 hrs. • Drug is eliminated primarily as metabolites in urine (8086%).

Phenylephrine Hydrochloride Stimulates

Mode of Action

Symphathetic adrenergic nerve endings Norephinephrine Alpha & Beta receptors

Vasoconstriction Acts as Nasal Decongestant

Dosage Phenylephrine Hydrochloride • Adult: 10 mg every 4 hours

• Children: 0.15mg/kg mg every 4 hours

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Paracetamol • Effective alternative to aspirin as analgesic & antipyretic.

• Less toxicity and most widely preferred. • Rapidly and completely absorbed from GI tract.

• Peak plasma concentration reaches within 30-60 minutes • Plasma Half-life is about 2 hours after therapeutic dose.

Chlorpheniramine Maleate • H1 receptor antagonist. • One of the most potent antihistamines. • One of the most effective and least toxic antihistamine.

• Effective in relatively low doses (2mg-4mg). • Prevents histamine from dilating capillaries that causes oedema of respiratory mucosa. • Promptly relieves symptoms in Rhinitis (sneezing, itching of eyes, nose & throat). Sales Training

Dosage Chlorpheniramine Maleate

• In children upto 1 year dose is 1mg twice daily. • For those aged 1 to 5 years 1 to 2 mg three times daily. • For 6 to 12 years, 2 to 4 mg 3 or 4 times daily.

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Alex Cough Lozenges Composition Each Lozenge contains : • Dextromethorphan Hydrobromide I.P. 5 mg • Sugar base q. s.

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Alex Cough Lozenges Profile • Unique product, was introduced for the first time in India. • Word 'Lozenges' is from old French word 'Lauze' meaning a flat stone.

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Alex Cough Lozenges Profile • The medical definition of Lozenges is tablet containing medication in flavoured and sweetened base.

• Designed for local treatment of throat by slow & steady release of the medicine in the mouth.

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Actions of Alex Cough Lozenges • Demulcent Action base of Lozenges offer protective barrier over inflamed mucous membrane. • Promote mucus secretion : an important defense mechanism of respiratory tract. • Provides longer time with mucous membrane - unlike with syrup preparations. Sales Training

Alex Cough Lozenges Indications • Mainly used for non-productive, irritative cough. • When antitussive action & demulcent action is required.

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Alex Cough Lozenges Dosage Adults and children

:

1-2 Lozenges every 68hours.

: : :

1 Lozenge 3-4 times a day. As directed by Physician. Not recommended.

above 12 years Children 6 to 12 years 4 to 6 years < 4 years

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Available in strip of 10s. 10 strips are in an outer carton. Sales Training

Alex Cough Formula Composition Each 5 ml contains : • Guaiphenesin • Dextromethorphan Hydrobromide

100 mg 10 mg

• Phenylephrine

5 mg

• Chlorpheniramine maleate

4 mg

• Flavoured base Sales Training

q.s.

Alex Cough Formula Indications Recommended in cases of Productive Cough and cold due to LRTI. i.e. to tackle various types of cough and associated symptoms.

Alex Cough Formula Dosage Adults & Children: Above 12 years teaspoonful(10 ml) 3-4 times a day.

2

6 years to 11 years- 1 teaspoonful(5 ml) 3-4 times a day. 1 year to 5 years - 1/2 teaspoonful(2.5 ml) 3-4 times a day.

Less than 1 yr- Not recommended. Sales Training

Alex Cough Formula Precautions Patients should be advised to abstain from

taking

alcohol

or

depressants concomitantly.

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other

CNS

Available in 50 & 100 ml pet bottles.

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Alex Sugar Free Syrup Rationale Ideal for ... • Diabetic patients

• Calorie Conscious patients • Patients with dental problems

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Alex Sugar Free Syrup Choice of Sweetener ALEX Sugar Free is sweet and palatable: Due to SORBITOL (70% w/w) in place of sugar.

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Available in 50 ml pet bottle Sales Training

Alex-P Syrup Composition Each 5ml contains : • Paracetamol • Dextromethorphan Hydrobromide

170mg 5mg

• Phenylephrine Hydrochloride

2.5mg

• Chlorpheniramine Maleate

1.5mg

• Flavoured base Sales Training

q.s

Alex-P Syrup Indications • Indicated in the treatment of cold, fever, and pain relief in rhinitis,

pharyngitis, upper respiratory tract infections and sinusitis.

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Alex-P Syrup Dosage Adults

& Children: Above 12 years - 2 teaspoonful(10 ml) 3-4 times a day. 6 years to 11 years- 1 teaspoonful(5 ml) 3-4 times a day. 1 year to 5 years - 1/2 teaspoonful(2.5 ml) 3-4 times a day.

Less than 1 yr- Not recommended. Sales Training

Available in bottle of 60 ml pet bottle with a measuring cap.

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Alex Paediatric Drops Composition Each ml contains : • Phenylephrine Hydrochloride

• Chlorpheniramine Maleate • Flavoured base

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2.5 mg

2 mg q.s.

Alex Paediatric Drops Rationale • Phenylephrine is most frequently used decongestants, equipotent to ephedrine, with less CNS stimulation.

• Chlorpheniramine Maleate possesses good antihistaminic activity with less sedative and anticholinergic effects. • Both together clear a blocked nose. Sales Training

Alex Paediatric Drops Indications Recommended for the symptomatic relief of colds

and

allergic

symptoms

including

running nose, stuffy nose, sneezing, itching of the

nose

or

water eyes. Sales Training

throat

and

itchy,

Alex Paediatric Drops Dosage • 4 - 12 months hours

0.6 ml every 4 to 6

• 12 - 24 months hours

1.25 ml every 4 to 6

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Available in 15 ml bottle with dropper. Sales Training

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